摘要
目的:探讨新疆地区汉族、维吾尔族宫颈癌与抗核抗体(ANA)的相关性及民族间差异。方法:应用间接免疫荧光法(IIF)检测65例汉族宫颈癌患者(H组)、130例汉族对照(HC组)、55例维吾尔族宫颈癌患者(U组)及55例维吾尔族对照(UC组)的血清ANA,并分析它们之间的差别及年龄与ANA之间的相关性。结果:ANA阳性率结果比较,H组高于HC组、U组高于UC组、UC组高于HC组(χ2分别为34.96、8.75和6.86,均P<0.01);H组、U组比HC组、UC组在ANA荧光模型、靶抗原细胞定位上显示出更加丰富的荧光模式;抗核仁抗体阳性率结果比较,H组高于HC组(χ2=7.42,P<0.01)、U组高于UC组(χ2=5.24,P<0.05);HC组低于UC组(P=0.03),H组低于U组(χ2=3.91,P<0.05);4组ANA阳性率均呈随年龄增长而升高的趋势。结论:新疆地区汉族、维吾尔族宫颈癌与ANA具有相关性,且存在民族差异性。
Objective： To study the relationship between anti-nuclear antibodies （ANA） and cervical cancer in Hans and Uygurs nationalities of Xinjiang and the national difference thereof. Methods： The levels of ANA in sera were detected in cervical cancer patients of Hans （H group, n=65）, controls of Hans （HC group, n=130）, cervical cancer patients of Uygurs（U group, n=55） and controls of Uygurs（UC group, n=55） by indirect immunofluorescence （IIF）. Results： The positive rate of ANA was higher in H group compared to that of HC group. The positive rate of ANA was higher in U group compared to that of UC group （X2 = 34.96,8.75,6.86, P 〈 0.01）. The fluorescence pattern and the localization of target antigens were more abundant in cells of H and U groups than those of HC and UC groups （X2= 7.42,P 〈 0.01）. The positive rate of anti-nuclear antibody was higher in U group than that of UC group （X2 = 5.24 ,P 〈 0.05）. The positive rate of anti-nuclear antibody was lower in HC group than that of UC group （P = 0.03）, and was lower in H group compared to that of U group （X2 = 3.91 ,P 〈 0.05）. The positive rate of ANA was increased with increase in age in four groups. Conclusion： There is a correlation between antinuclear antibodies and the cervical cancer in both Hans and Uygurs nationalities, and otherness between Hans and Uygurs.
出处
《天津医药》
CAS
北大核心
2009年第9期721-723,共3页
Tianjin Medical Journal
基金
国家自然科学基金资助项目(项目编号:30660193)
