摘要
目的:探讨王不留行对血管生成的抑制作用。方法:采用MTT法及M atrigel p lug法测定王不留行提取物对人血管内皮细胞(HMEC)增殖、迁移及小管形成的影响。结果:王不留行提取物可显著抑制HMEC细胞的体外增殖(IC50为50μg/mL)与迁移,并呈明显的量效关系,同时还能抑制M atrigel p lug模型中的血管新生。结论:王不留行提取物能显著抑制血管生成,有可能成为一种有效的血管生成抑制剂。
Objective：To study the inhibiting effect of Vaccaria segetalis extracts on neovascularization. Methods：The effect of Vaccarla segetalis extracts on the proliferation.migration in vitro and tube formation on Matrigel of endothelial cell（ HMEC ）in vivo were examined by MTT assay and Matrigel plug assay. Results：The proliferation and migration of HMEC were inhibited significantly by Vaccaria segetalis extracts in a dose-dependent manner （IC50 = 50μg/mL ）. It also inhibited angiogenesis in Matrigel plug mouse model. Conelusion：Vaccaria segetalis extracts can inhibit angiogenensis obviously, and it could be developed as an effective antiangio- genie drug.
出处
《中药材》
CAS
CSCD
北大核心
2009年第8期1256-1259,共4页
Journal of Chinese Medicinal Materials
基金
国家自然科学基金(30772586)
