期刊文献+

外周血抵抗素水平在2型糖尿病合并高血压患者中的意义

The value of resistin level in peripheral blood of patients with coexistence of type 2 diabetes and hypertension
原文传递
导出
摘要 目的探讨检测2型糖尿病(T2DM)合并高血压(HT)患者外周血中抵抗素的意义。方法选择2006年3月至2007年12月内分泌科与心脏科住院患者为研究对象,并设对照组。入选患者分为4组:单纯T2DM(A组,28例),T2DM合并HT组(B组,26例),单纯HT组(C组,30例),健康对照组(对照组,25例)。分别检测4组的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)以及抵抗素水平,同时应用颈动脉超声测量颈内/外动脉的最大内中膜厚度(IMT),并探讨它们之间的关系。结果HT合并T2DM组患者外周血抵抗素水平明显高于其他3组〔(39.0±16.4)ng/ml vs(14.5±8.8)ng/ml、(14.3±5.6)ng/ml、(10.3±3.3)ng/ml,P均<0.05〕,对该组进行以血糖为因变量的多元回归分析发现,血糖的变化与年龄、BMI、舒张压和收缩压及血清抵抗素水平有关,进行年龄、BMI和血压调整后,血糖水平仍然与外周血抵抗素水平有关。结论外周血抵抗素水平是HT合并T2DM的独立危险因子。 Objective To investigate the value of detecting resistin level in peripheral blood of patients with coexistence of type 2 diabetes (T2DM) and hypertension (HT). Methods Eligible patients were all admired in departments of endocrinology and cardiology from March 2006 to December 2007. Following groups were studied:T2DM alone group (group A, n = 28), T2DM complicated with HT group (group B, n=26), HT alone group (group C, n =30), normal control group (control group, n =25). Fasting blood glucose (FBG), HbAlc, cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and serum resistin were detected in separate groups; the maximum intra-mid membrane thickness (IMT) of inner/outside carotid artery was measured as well; the relations among above indexes were studied. Results The resistin level in group B was obviously higher.than that in other three groups[ (39. 0 ± 16. 4) ng/ml vs ( 14. 5 ±8. 8 ) ng/nd, ( 14. 3 ± 5.6) ng/ml, ( 10. 3 ± 3. 3 ) ng/ml, respectively, all P 〈 0. 05 ). The glucose level showed correlation with age, body mass index (BMI) ,systolic/diastolic blood pressure and serum resistin level by multiple regression analysis; the glucose level was still correlated with serum resistin level after adjusting age, BMI and blood pressure. Conclusions Resistin level in peripheral blood is an independent risk factor of coexistence of T2DM and HT.
出处 《中国厂矿医学》 2009年第4期390-392,共3页 Chinese Medicine of Factory and Mine
关键词 高血压 2型糖尿病 抵抗素 Hypertension Type 2 diabetes Resistin
  • 相关文献

参考文献8

  • 1Kannel WB, McGee DL. Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham Study [ J]. Diabetes Care, 1979,2(2) :120 - 126.
  • 2Savoia C, Schiffrin EL. Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions [ J]. Clin Sci (Lond) ,2007,112 ( 7 ) :375 - 384.
  • 3Takata Y, Osawa H, Kurata M, et al. Hyperresistinemia is associated with coexistence of hypertension and type 2 diabetes[J]. Hypertension, 2008,51 (2) :534 -539.
  • 4Steppan CM,Bailey ST,Bhat S,et al. The hormone resistin links obesity to diabetes[ J]. Nature ,2001,409(6818) :307 -312.
  • 5Zhang JL, Qin YW, Zheng X, et al. Serum resistin level in essential hypertension patients with different glucose tolerance[ J ]. Diabet Med, 2003,20(10) :828 - 831.
  • 6Furuhashi M, Ura N, Higashiura K, et al. Circulating resistin levels in essential hypcrtension[J]. Clin Endocrinol (Oxf) ,2003,59 (4) :507 -510.
  • 7成兴波,范庆涛.2型糖尿病合并高血压患者抵抗素与动脉粥样硬化的相关性研究[J].标记免疫分析与临床,2006,13(4):215-217. 被引量:8
  • 8章建梁,秦永文,郑兴,邱健力,丁继军,卞金陵,袁文俊.血清抵抗素浓度与血压的相关性研究[J].解放军医学杂志,2003,28(3):241-242. 被引量:26

二级参考文献11

  • 1罗佐杰,张英,梁杏欢,陈青云,卢德成,戴霞,何云,李智贤,李艳宁.2型糖尿病患者抵抗素、颈动脉内膜中层厚度水平变化研究[J].广西医科大学学报,2004,21(2):160-162. 被引量:4
  • 2[1]Steppan CM, Bailey ST, Bchat S et al. The hormone resistin links obesity to diabetes. Nature, 2001, 409:307
  • 3[2]Steppan CM, Yamazawa T, Brown EJ et al. Antagonism of insulin action by resistin. Diabetes, 2001, 50(Suppl 2):A70
  • 4[3]Ferrannini E, Natali A, Capaldo B et al. Insulin resistance, hyperinsulinemia, and blood pressure. Role of age and obesity. Hypertension,1997, 30:1144
  • 5[4]Deurenberg P, Weststrate JA, Seidell JC. Body mass index as a measure of body fatness: age-and sex-specific predition formulas. Br J Nutr,1991, 65:105
  • 6Steppan C M,Bailey S T,Bhat S,et al.The hormone resistin links obesity to diabetes[J].Nature,2001,409:307-312.
  • 7Steppan C M,Lazar M A.Resistin and obesity associated insulin resistance[J].Trends Endocrinol Metab,2002,1(1):18-23.
  • 8UKPDS group.UK prospective diabetes study 17.A nine-year update of a randomized.controlled trial on the effect of improved metabolic control on complications in non-insulin-dependant diabetes mellitus[J].Ann Intern Med,1996,124-134.
  • 9Psaty B M,Furberg C D,Kuller L H,et al.Isolated systolic hypertension and subclinical cardiovascular disease in the elderly.Initial findings from the cardiovascular health study[J].JAMA,1992,268(10):1287.
  • 10章建梁,秦永文,郑兴,邱健力,毛红娟,龚莉,邹大进.不同糖耐量状态的原发性高血压患者血清抵抗素水平[J].中华内分泌代谢杂志,2002,18(3):233-235. 被引量:66

共引文献32

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部