摘要
目的探讨生存素(Survivin)、环氧合酶-2(COX-2)在胃癌组织中的表达及其临床意义。方法应用免疫组化S-P技术检测Survivin、COX-2在慢性浅表性胃炎(CSG)12例、慢性萎缩性胃炎(CAG)15例、不典型增生(Dys)10例、胃癌(GC)60例组织中的表达情况。结果在CSG、CAG、Dys和GC组织中,Survivin的表达率分别为0、26.7%、60.0%和75.0%,COX-2的表达率分别为0、20.0%、50.0%和70.0%,在癌前病变阶段二者的表达即开始逐渐增加;Survivin、COX-2在胃癌组织中的表达与淋巴结转移、肿瘤浸润深度以及TNM分期有关(P均<0.05)。结论Survivin、COX-2与胃癌的生长和浸润转移关系密切,可能参与胃癌的发生与发展。
Objective To investigate the expression of Survivin and Cyclooxygenis-2 （COX-2） and their relationship with the clinical feature of gastric carcinoma. Methods In 97 specimens sampling from tissues of chronic superficial gastritis（ n = 12） ,chronic atrophic gastritis （n = 15） ,dyshyporplasia（n = 10） and gastric carcinoma（n =60） ,the expressions of Survivin and COX-2 here were detected by immunohistochemistry. Results Of the 60 cases of gastric carcinoma, 45 cases expressed Survivin （75.0%） , and 42 cases expressed COX-2 （70. 0% ）. The expressions of Survivin and COX-2 in gastric carcinoma were significantly higher than that in gastric precancerous lesion（ all P 〈0. 05）. The expressions of Survivin and COX-2 in gastric carcinoma were associated with lymph node metastasis,infiltration depth and TNM stage （all P 〈 0. 05 ）. Conclusions The high expressions of Survivin and COX-2 in gastric carcinoma suggest that they play important roles in the development and metastasis of gastric carcinoma.
出处
《中国厂矿医学》
2009年第4期397-398,共2页
Chinese Medicine of Factory and Mine
关键词
生存素
环氧合酶-2
胃肿瘤
免疫组织化学
Survivin
Cyclooxygenise-2（COX-2）
Gastric carelnoma
Immunohistochemistry
