摘要
目的优选多效胃镜乳的制备工艺。方法以乳剂的稳定性和外观为考察指标,以乳化剂用量、水相(未加单糖浆)pH和乳化温度为可变因素,用L9(34)表进行正交试验。结果最优的制备工艺是7mL乳化剂司盘-80和14g西黄蓍胶,水相(未加单糖浆)pH=4,乳化温度85℃。结论按最佳工艺制备的多效胃镜乳符合2000年版《中国药典》的规定。
Objective To optimize the preparation technology for multi-effect gastroseope emulsion. Methods The stability and appearance of the emulsion were used as the evaluating targets, the orthogonal design method table L9（3^4） was used. Emulsifiers, water-phase （without simple syrup） pH and temperature of the emulsion were selected as the variable factors. Results The optimum technology was Span- 80 mL, tragacanth 14 g, water- phase （without simple syrup）pH =4 and the emulsifying temperature 85 ℃. Conclusion The multi- effect gastroscope emulsion prepared by this technology accords with the stipulation of Chinese Pharmacopoeia（2000 edtion）.
出处
《中国药业》
CAS
2009年第17期30-31,共2页
China Pharmaceuticals
关键词
多效胃镜乳
正交试验
制备工艺
multi - effect gastroscope emulsion
orthogonal design
technology
