Sjogren综合征发病机制及治疗进展
摘要
Sjogren综合征是一种系统性自身免疫性疾病,主要累及泪腺和唾液腺等外分泌腺,导致进行性眼干和口干等症状。此文将对Sjogren综合征发病机制和治疗的研究进展进行综述。
出处
《中国实用眼科杂志》
CSCD
北大核心
2009年第8期792-796,共5页
Chinese Journal of Practical Ophthalmology
参考文献32
-
1M. Ramos-Casals and J. Font. Primary Sjogren's syndrome:current and emergent aetiopathogenic concepts [J].Rheumatology,2005,44: 1354-1367.
-
2Ohlsson MR, Brokstad KA. Subcellular redistribution and surface exposure of the Ro52, Ro60 and La48 autoantigens during apoptosis in human ductal epithelial cells : a possible mechanism in the pathogenesis of Sjogren' s syndrome[J].Scand Immunol, 2002,56(5 ) : 456-469.
-
3Alexander Espinosa.The Sjogren's Syndrome-Associated Autoantigen Ro52 Is an E3 Ligase That Regulates Proliferation and Cell Death[J]. The Journal of Immunology, 2006, 176 : 6277-6285.
-
4Katsushi Miyazaki, Noriaki Takeda, Naozumi Ishimaru, Fumie Omotehara, Rieko Arakaki, and Yoshio Hayashi. Analysis of in Vivo Role of α-Fodrin Autoantigen in Primary Sjogren's Syndrome [J].American Journal of Pathology,2005,167 (4) : 1051-1059.
-
5C Sordet, JE Gottenberg, J Goetz, D Bengoufa, R-L Humbel, X Mariette, J Sibilia. Anti-α-fodrin autoantibodies are not useful diagnostic markers of primary Sjogren' s syndrome [J]. Annals of the Rheumatic Diseases, 2005,64:1244-1245.
-
6Dokmanovic-Miletic M.P.,Stojanovic R.M.,Pajic O;etal. Milenkovic. Incidence of anti-alfa fodrin antibodies in primary Sjogren syndrome and its correlation with anti RO/SS-A ang anti LA/SS-B antibodies[J]. Annals of the Rheumatic Diseases, 2006,65 (2) : 299.
-
7Willeke P, Gaubitz M, Schotte H, et al. Domschke and B. Schl titer. Clinical and immunological characteristics of patients with Sjogren's syndrome in relation to α-fodrin antibodies [J]. Rheumatology, 2007,46(3 ) : 479-483.
-
8Barone F ,Bombardieri M ,Spencer J ,et al. Valesini and C. Pitzalis. Aberrant expression of B cell survival factors in salivary gland MALT lymphomas in Sjogren's syndrome [J]. Annals of the Rheumatic Diseases, 2006,65 ( 2 ) : 470.
-
9王建光,杨新宇,王建敏,郑巧敏,金丽琴,邢凤友.pSS患者唇腺组织中Fas介导的凋亡信号蛋白的表达[J].中国病理生理杂志,2006,22(11):2177-2180. 被引量:8
-
10Dawson,L. J. Fox and P. C.Smith P. M. Sjogren's syndrome-the non-apoptotic model of glandular hypofunction [J]. Rheumatology, 2006,45 : 792-798.
二级参考文献23
-
1Willeke P,Schotte H,Schluter B,et al.Interieukin 1 beta and tumour necrosis factor alpha secreting cells are increased in the peripheral blood of patients with primary Sjogren's syndrome.Ann Rheum Dis,2003,62:359-362.
-
2Garcic-Carrasco M,Font J,Filella X,et al.Circulating levels of Th1/Th2 cytokines in patients with primary Sjogren's syndrome:correlation with clinical and immunological features.Clin Exp Rheumatol,2001,19:411-415.
-
3Fox RI,Kang HI,Ando D,et al.Cytokine mRNA expression in salivary gland biopsies of Sjogren's syndrome.J Immunol,1994,152:5532-5539.
-
4Azuma M,Motegi K,Aota K,et al.Role of cytokines in the destruction of acinar structure in Sjogren's syndrome salivary glands.Lab Invest,1997,77:269-280.
-
5Zoukhri D,Hodges RR,Byon D,et al.Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia.Invest Ophthalmol Vis Sci,2002,43:1429-1436.
-
6Tornwald J,Fox H,Edwards C,et al.Treatment with pegylated recombinant methionyl human soluble tumor necrosis factor-type1 receptor (PEG sTNF-R1) prevents development of Sjogren's syndrome and diabetes in the NOD mouse model.Arthritis Rheum,2000,42 (Suppl 9):403-409.
-
7Steinfeld SD,Demols P,Salmon I,et al.Infliximab in patients with primary Sjogren's syndrome:a pilot study.Arthritis Rheum,2001,44:2371-2375.
-
8Goillot EM,Touraine JL.Sialadenitis in nonobese diabetic mice transfer into syngesetic healthy neonates by splen T lymphocytes.Clin Immunol Immunopathol,1991 59:462-466.
-
9Yamano S,Atkinson JC,Baum BJ,et al.Salivary gland cytokine expression in NOD and normal BALB/c mice.Clin Immunol,1999,92:265-275.
-
10Yamakawa M,Weinstein R,Tsuji T,et al.Age-related alterations in IL-1 beta,TNF-alpha,and IL-6 concentrations in parotid acinar cells from BALB/c and non-obese diabetic mice.Histochem Cytochem,2000,48:1033-1042.
共引文献19
-
1王振刚.改变病情的抗风湿药物(一)[J].临床药物治疗杂志,2008,6(4):39-45. 被引量:1
-
2黄慈波,程永静,王芳,高洁,牛素平,赵籥陶.用cDNA基因芯片技术分析原发性干燥综合征免疫细胞及信号相关基因的表达[J].中华临床免疫和变态反应杂志,2009,3(1):16-20. 被引量:1
-
3尹心宝,林天歆,许可慰,黄海,江春,韩金利,黄健.13-甲基十四烷酸诱导膀胱癌细胞株T24凋亡的机制研究[J].中国病理生理杂志,2009,25(7):1266-1270. 被引量:5
-
4朱峪英,凌雄.正清风痛宁配合西药治疗类风湿关节炎67例[J].陕西中医,2010,31(12):1615-1617. 被引量:7
-
5陆莉君,钱先.生津方治疗干燥综合征临床研究[J].成都中医药大学学报,2011,34(1):30-32. 被引量:5
-
6张华东,陈祎,姜泉,殷海波,徐世杰,孔丽,黄梦媛,于志谋,杜辉.路氏滋燥汤对小鼠颌下腺细胞因子Fas/FasL的影响[J].北京中医药,2011,30(4):249-251. 被引量:2
-
7张水艳,郭刚,梁静,李惠云,张海顺,朱秀惠,武占成,张韶英.自拟金菊清润胶囊治疗原发性干燥综合征30例临床观察[J].疑难病杂志,2011,10(11):835-838. 被引量:8
-
8董菽茜.羟氯喹对原发性干燥综合征患者ESR、CRP等指标的影响[J].中国医学创新,2012,9(24):91-92. 被引量:3
-
9康媛媛,孙富丽,张英,孙妍.Smac在干燥综合征患者唇腺组织中的表达[J].实用口腔医学杂志,2013,29(1):53-55. 被引量:7
-
10魏瑞华,郝永娜,边领斋,李雪,粘红,赵少贞.Sjgren综合征相关性干眼发病机制的研究进展[J].眼科新进展,2013,33(3):286-289. 被引量:4
-
1吴晓梅,黄雨梅,张静仪,卢吉勇.Sjogren综合征泪液的免疫检测[J].华西医学,1995,10(4):391-392.
-
2蒙碧辉,梁杏欢.Sjogren综合征致肾小管酸中毒和骨质疏松1例[J].广西医科大学学报,2003,20(1):28-28.
-
3俞创奇,邱蔚六,胡北平,陆昌语.舍格伦综合征的发病机理和病因研究现状[J].上海口腔医学,1999,8(3):184-186. 被引量:7
-
4邵玉红,张汗承.正常人与Sjogren综合征患者唇腺免疫细胞的研究[J].眼科研究,2003,21(4):421-421.
-
5胡宗德,麦静愔.全身炎症反应综合征的研究进展[J].世界感染杂志,2006,6(5):407-409. 被引量:1
-
6赵雪梅.X光影像诊断颈椎病临床分析[J].中国现代药物应用,2010,4(7):36-36. 被引量:3
-
7吴仕静.消化内科住院患者恶心呕吐的病因分析[J].求医问药(下半月刊),2011,9(10):69-70. 被引量:3
-
8魏瑞华,郝永娜,边领斋,李雪,粘红,赵少贞.Sjgren综合征相关性干眼发病机制的研究进展[J].眼科新进展,2013,33(3):286-289. 被引量:4
-
9华红,徐治鸿,夏淑君.Sjōgren综合征女性患者外周血性激素水平的变化[J].现代口腔医学杂志,1996,10(1):23-24. 被引量:6
-
10汤建平轩,刘晓华轩,沈友轩.唇腺病理对Sjogren综合征的诊断价值探讨[J].汕头大学医学院学报,1999,12(2):29-30. 被引量:1