摘要
目的探讨熊去氧胆酸(UDCA)联合多潘立酮对原发性胆汁反流性胃炎的治疗作用。方法156例原发性胆汁反流性胃炎病人随机分3组。UDCA组予UDCA 250 mg,1次/d,口服;多潘立酮组给予多潘立酮10 mg,3次/d,口服;UDCA联合多潘立酮组给予UDCA 250 mg,1次/d,口服;联合多潘立酮10 mg,3次/d,口服。3组疗程均为8周。采用临床疗效和胃镜随访量化表进行问卷调查,并建立病人的资料档案。结果UDCA联合多潘立酮对原发性胆汁反流性胃炎临床症状总有效率、胃镜征象改变有效率均高于UDCA组和多潘立酮组(P<0.05);且H.pylori阳性与H.pylori阴性患者疗效无显著性差异(P>0.05)。结论UDCA联合多潘立酮能有效缓解胆汁反流性胃炎临床症状;H.pylori对其疗效可能无干扰作用。
Objective To investigate the therapeutic effect of Ursodeoxycholic acid （UDCA） combined with Domperidone on patients with primary biliary reflux gastritis. Methods Ooe hundred and fifty-six patients with primary biliary reflux gastritis were randomly divided into three groups. The UDCA group was given UDCA 250 mg daily by peroral ad- ministration for 8 weeks, meanwhile the Domperidone group was given Domperidone 10 mg thrice a day by peroral administration. And the UDCA combined with Domperidone group was given UDCA 250 mg daily and Domperidone 10 mg thrice a day for 8 weeks. Questionnaire survey of the clinical efficacy and quantitative endoscopic follow-up was conducted to establish the patients＇ data files. Results The total effective rate of primary biliary reflux gastritis in the UDCA combined with Domperidone group was significantly higher than that in the UDCA group and the Domperidone group （P 〈0.05）. The gastroscopy examination showed that the improvement rate in the UDCA combined with Domperidone group was significantly higher than that in the UDCA group and the Domperidone group （P 〈 0.05）. There was no significant difference of effective rate between the patients with H. pylori positive and negative （P 〉 0.05）. Conclusion UDCA combined with Domperidone can effectively alleviate the clinical symptoms of primary biliary reflux gastritis and H. pylori may not interfere this effect.
出处
《胃肠病学和肝病学杂志》
CAS
2009年第8期732-734,共3页
Chinese Journal of Gastroenterology and Hepatology
