摘要
目的:比较盐酸尼莫司汀(ACNU)经静脉持续小剂量滴注与常规静脉滴注的临床疗效。方法:选取2004年～2006年30例经病理证实的恶性胶质廇病人,并且经过常规手术和放疗后,随机20例为24h小剂量滴注组,另10例为常规2h给药组。每组间隔1月行第二个疗程,共6个疗程。结果:实验组灌注治疗的完全反应(CR)、部分反应(PR)高于对照组(P<0.05):实验组、对照组平均生存期分别为(22.2±8.25)月和(14.23±7.62)月,实验组生存期也长于对照组(P<0.05),两组有显著性差异。结论:ACNU持续小剂量给药治疗脑胶质瘤的临床疗效优于常规给药。
Objective： To compare the clinical treatment efficacy of the Glioma by low-dose continuous infusion ACNU and conventional- dose. Methods： From 2004 to 2006, 30 postoperative and post radiotherapy patients with pathologically confirmed malignant Glioma were divided randomly into experiment group （n=20） and Control group （n=10） .In the experiment group, ACNU （2.5 mg/kg） was infused in 24 h, while the control group was infused in 2h. Each group was infused once per month for six times. Results： CR and DR of the experiment group were higher than that of the control group. The survival duration （14.23±7.62） months of the experiment group was longer than that of the control group （22.2±8.25 ） months, and there was a statistically significant difference between the two groups. Conclusion： The therapeutic effects of ACNU by continue small-volume infusion in treating Glioma is better than that with usual method.
出处
《中国医药导刊》
2009年第8期1318-1319,共2页
Chinese Journal of Medicinal Guide
基金
江苏省肿瘤医院青年科技基金项目(编号:ZQ200418)
