期刊文献+

代谢性疾病实验动物模型的建立与评价 被引量:5

Establishment and Evaluation of Laboratory Animal Models of Metabolic Diseases
下载PDF
导出
摘要 代谢综合征是一组以多种代谢性疾病合并出现为临床特点的临床症候群。建立适合的MS动物模型对研究代谢性疾病的发病机理和相关药物筛选有十分重要的意义。本文就目前MS实验动物模型的建立做一综述,并对其进行评价。 Metabolic syndrome(MS) is a group of clinical syndromes,and it is characteristic as a combination of several kinds of metabolic disorders.It is of great significance to establish suitable animal models of MS on research of pathogenesis and related drug screening for metabolic diseases.This article introduces a review and evaluation of the current laboratory animal models of metabolic syndrome.
出处 《中国实验动物学报》 CAS CSCD 2009年第4期318-320,I0005,I0006,共5页 Acta Laboratorium Animalis Scientia Sinica
基金 高等学校博士学科点专项科研基金(编号:20070026015)
关键词 代谢综合征 动物模型 评价 Metabolic Syndrome Animal Models Evaluation
  • 相关文献

参考文献24

  • 1张敏,宋秀霞,姜涛.高尿酸血症与代谢综合征的相关性分析[J].中国现代医学杂志,2008,18(5):623-625. 被引量:44
  • 2Cefalu WT. Animal models of type 2 diabetes: clinical presentation and pathophysiologieal relevance to the human condition [J]. ILAR J,2006,47 (3) : 186 - 198.
  • 3毕秀萍,张薇.代谢综合征动物实验模型的研究进展[J].中国动脉硬化杂志,2006,14(11):1007-1009. 被引量:8
  • 4Zhang Y, Proenca R, maffei M, et al. Positional cloning of the mouse obese gene and its human homologue[J]. Nature, 1995,374 (652): 479.
  • 5郭江宏,管耘圆.代谢相关综合征动物模型的研究进展[J].实验动物科学与管理,2006,23(1):39-41. 被引量:8
  • 6Ito T, TanimotoM, Yamada K, et al. Glomerular changes in the KKA3CTa mouse: a possible model for human type 2 diabetic nephropathy [ J ]. Nephrology ( Carlton ), 2006,11 ( 1 ) : 29 - 35.
  • 7李聪然,游雪甫,蒋建东.糖尿病动物模型及研究进展[J].中国比较医学杂志,2005,15(1):59-63. 被引量:93
  • 8Pravenec M, Zidek V, Landa V, et al. Genetic analysis of cardiovascular risk factor clustering in spontaneous hypertension[ J]. Folia Biol (Praha) ,2000,46 (6) :233 - 240.
  • 9Qu x, Donnelly R. Is insulin resistance in the spontaneously hypertensive rat related to changes in protein kinase C in skeletal muscle? [J]. Am J Hypertens, 1997,10(9) : 1053 - 1057.
  • 10Velliquette RA, Koletsky R J, Ernsberger P. Plasma glucagon and free fatty acid responses to a glucose load in the obese spontaneous hypertensive rat (SHROB) model of metabolic syndrome X[J]. Exp Boil Med (Maywood) ,2002,227(3) : 164 - 170.

二级参考文献134

共引文献192

同被引文献53

  • 1程霄瀚,刘莉,隋艳波,邹国良,金娟.喂养型代谢综合征大鼠模型成模率分析[J].山东医药,2013,53(37):15-17. 被引量:9
  • 2杨国庆,陆菊明,柳红芳,马芳龄,邹效漫,潘长玉.高脂饮食诱导的胰岛素抵抗对大鼠血浆同型半胱氨酸水平的影响[J].军医进修学院学报,2005,26(1):9-11. 被引量:1
  • 3徐立,时乐.小鼠代谢性高尿酸血症模型的复制方法初探[J].中国比较医学杂志,2006,16(1):1-4. 被引量:33
  • 4Kastorini CM, Milionis HJ, Ioannidi A, et al. Adherence to' the Mediterranean diet in relation to acute coronary syndrome or stroke nonfatal events : a comparative analysis of a case7 case con trol study[J]. Am Heart J,20111162(4) :717.
  • 5Dobrian AD, Davies MJ, Prewitt RI., et al. Development of hyper tension in rat model of diet-induced obesity[J]. Hypertension, 2000,35 (4) :1009.
  • 6Blsbal C, Lambert K, Avignon A. Amioxidants and glucose me tabolisrn disorders[J]. Ct!rr Opin Clin Nutr Metab Care, 2010,13 (4) :439.
  • 7Henriksen EJ, Diamond-Stanic MK, Marchionne EM. Oxidative stress and the etiology of insulin resistance and type2 diabets[J]. Hypertension, 2000,35 ( 4 ) : 1009.
  • 8Dario P, Francesco Z, Enrico D S, et al. Oxidative Stress, Nitric Oxide, and Diabetes[J]. Rev Diabet Stud, 2010,7 (1) : 15.
  • 9Kim MS,Park JY,Namkoong C,et ah Anti-obesity effects or al- pha-lipoie acid mediated by suppression of hypothalamic AMP ac tivated protein kinase[J]. Nat Med,2004,10:727.
  • 10Zhang Y,Han P,Wu N,et al. Amelioration of.iipid abnormalilies by a lipoic acid through antioxidative and anti-inflammatory effects[J]. Obesity (Silver Spring) ,2011,19(8) : 1647.

引证文献5

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部