摘要
目的观察环氧氯丙烷(EC)改性戊二醛(GA)处理对新鲜猪主动脉瓣膜根部尺寸的影响,为无支架主动脉瓣膜设计提供参考。方法测量40头猪主动脉瓣(新鲜组和处理组各20头)在根部不同水平的管口面积和瓣叶尺寸,研究瓣膜经处理后尺寸的变化。结果(1)在窦管交界上方1cm处(STJ1)、窦管交界(STJ0)、主动脉窦部(SINUS)、基底部(BASE)等4个水平上,新鲜组管口面积分别为(2.33±0.41)、(2.18±0.45)、(4.07±0.54)、(2.48±0.36)cm^2,固定组为(2.30±0.31)、(1.98±0.40)、(3.92±0.71)、(2.47±0.32)cm,两组瓣膜管口面积均符合SINUS〉BASE〉STJ1〉STJ0(P〈0.05);新鲜组瓣膜的根部尺寸均大于处理组,但差异无统计学意义(P〉0.05)。(2)新鲜组左(L)、右(R)、无(N)冠瓣的瓣叶面积分别为(3.10±0.44)、(3.41±0.46)、(2.54±0.32)cm^2,R〉L〉N(P〈0.05);处理组瓣叶面积分别为(2.26±0.32)、(2.49±0.47)、(2.04±0.35)cm^2,R〉L〉N,但仅R和N之间差异有统计学意义(P〈0.05)。结论EC改性GA处理对瓣膜主动脉壁尺寸的改变不明显,但对瓣叶尺寸的改变差异有统计学意义。
Objective: To provide the reference for the stentless aortic valve design by observing the influence of glutaraldehyde (GA) and epichlorohydrin (EC) treatment on the fresh porcine aortic root. Methods The orifice area of aortic roots and the dimensions of cusps for 40 porcine aortic valves (20 fresh and 20 treated valves) were measured to study the dimension variations of fresh valves by treatment. Results ( 1 ) One cm above the sino-tube ( STJ1 ) and at the sino-tube ( STJ0), sinus (SINUS) and aortic base (BASE) levels, the orifice areas of the fresh valves were respectively (2.33 ± 0.41 ), ( 2. 18 ±0.45), (4.07 ±0.54), (2.48 ±0.36) cm^2 ,and those of the treated valves were respectively (2.30 ± 0.31 ), ( 1.98 ± 0.40 ), ( 3.92 ± 0. 71 ), ( 2.47 ± 0.32 ) cm^2, respectively. The orifice areas of both groups conformed to the pattern as follows : SINUS 〉 BASE 〉 STJ1 〉 STJO ( P 〈 0. 05 ). All the dimensions at four levels in fresh group were larger than those in treated group, but there was no significant difference (P〈0.05). (2) The cusp areas of the fresh group were respectively (3.10 ±0.44), (3.41 ±0.46) , (2.54 ± 0.32) cm^2 ,following the laws:right coronary cusp (R) 〉 left coronary cusp (L) 〉 non-coronary cusp (N) ( P 〈 0.05 ), and those of the treated group were (2.26 ± 0.32 ), (2.49 ± 0. 47 ), (2.04 ± 0.35 ) cm^2 respectively, following the similar patterns, but statistical significance only existed between R and N (P 〈 0. 05). Conclusion The dimensions of porcine aortic roots weren' t largely changed by GA and EC treatment, but the cusps were changed statistically.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2009年第9期1185-1187,共3页
Chinese Journal of Experimental Surgery
基金
国家“863”计划资助项目(2006AA02A138)
关键词
戊二醛
环氧氯丙烷
主动脉
猪
Glutaraldehyde
Epiehlorohydrin
Aorta
Porcine