摘要
目的研究云锡矿工肺癌与ｃ┐ｆｏｓ癌基因关系。方法用原位杂交方法检测２０例云锡矿工肺癌（Ｍ组），２０例非云锡地区非矿工肺癌（ＮＭ组）以及１０例死于非肺部疾病患者的尸解肺组织（Ｃ组）中ｃ┐ｆｏｓ癌基因的过度表达情况。结果ｃ┐ｆｏｓ癌基因的过度表达Ｍ组５／２０（２５％），ＮＭ组１２／２０（６０％）和Ｃ组１／１０（１０％）。结论ｃ┐ｆｏｓ癌基因的过度表达和非云锡肺癌的发生有关，而与云锡肺癌发生的直接关系不明显，因此，云锡矿工肺癌与癌基因关系具有特殊性。癌旁增生上皮ｃ┐ｆｏｓ表达常呈阳性反应。
Objective The relation between cfos oncogene and the high incidence of Yunnan tin miners' lung cacer was investigated. Methods Twenty Yunnan tin miners' lung cancer samples (M),2O nontin miners' lung cancer samples (NM),and 10 noncancer lung tissue samples (C) were assayed for cfos products with hybridization in situ method. Results High expression of cfos was observed in 5/20(25%) samples of M group,12/20(60%) in NM group,and 1/10(10%) in C group. Conclusion It was suggested that high expression of cfos oncogene seems to be related to nontin miners' lung cancer rather than to Yunnan tin miners' lung cancer;therefore other causative factors should be searched for positive sign of cfos product in hyperplastic epithelium of pericancerous lung tissue can be seen.
出处
《肿瘤》
CAS
CSCD
北大核心
1998年第4期272-273,共2页
Tumor
基金
云南省应用基础研究基金
关键词
云锡矿工
肺肿瘤
C-FOS
原位杂交
Yunnan tin miners Lung cancer cfos Hybridization in situ
