摘要
目的：通过对宫颈人类乳头状瘤病毒感染的筛查及追踪，找出高危因素，确定筛查及追踪对象，进一步提高防癌效果。方法：联合采用ＰＣＲ等方法对３０７例门诊妇女宫颈进行人类乳头状瘤病毒（ＨＰＶ）感染的检测。对假定的高危因素进行相关分析。对ＨＰＶ中的６／１１型和１６／１８型两组型别进行检测，对比两组型别感染者在细胞学及病理组织学方面的结果及追踪后的变化。结果：在外阴疣、宫颈糜烂、妊娠及年龄较轻的妇女中，宫颈ＨＰＶ感染率较高；以ＨＰＶ１６／１８型感染与癌前病变及癌关系密切。结论：提示要着重检测具有外阴疣、宫颈糜烂及妊娠妇女的宫颈ＨＰＶ感染状况并以１６／１８型阳性者作为追踪对象，如能与目前常用的细胞学普查措施配合可更有效地防癌。
Objective: Infection of human papilloma virus(HPV) in cervix was screened and followed up to find out high-risk factors, determine high-risk people and improve the efficiency of the prevention of cervix cancer. Methods: 307 women in our clinic were examined with PCR and other methods. Some high-risk factors were assumed and analyzed via regression. Two groups of HPV(type 6/11 and type 16/18)were detected separately to determine the differences in cytology, histopathology, and follow-up. Results:HPV cervixinfection rate was relatively higher in people with vulvar warts, cervix erosion and pregnancy. There is intimate relationship between HPV(type 16/18) infection and precancer/cancer. Conclusion:The detection should be focused on those who have vulvar wart, cervical erosion and pregnancy and the patient with 16/18 HPV positive should be followed up.
出处
《中山医科大学学报》
CSCD
1998年第3期223-226,共4页
Academic Journal of Sun Yat-sen University of Medical Sciences
关键词
乳头状瘤病毒
分离
提纯
病因学
宫颈肿瘤
诊断
papilloma virus, human/isolation & parification
cervix neoplasms/etiology
cervix neoplasms/diagnosis
