摘要
目的评价国产雷帕霉素洗脱支架与裸支架植入兔腹主动脉后不同时间血管再内皮化差异。方法雄性新西兰大白兔24只,高脂喂养28d后随机分为两组,分别于腹主动脉植入国产雷帕霉素洗脱支架Firebird(SES)和裸金属支架Mustang(BMS)。每组分别于术后第3、7、14和28天各处死3只动物,经处理后以扫描电镜观察支架段血管内皮,应用图像处理系统分析支架植入段血管再内皮化程度。结果支架植入术后第3天两组几乎均无新生内皮,炎症反应较明显。术后第7、14和28天,SES组内皮覆盖程度明显低于BMS组(分别为15%±8%比53%±9%;49%±16%比83%±4%和73%±3%比93%±4%,P<0.05)。结论SES植入后靶血管出现明显的再内皮化延迟。
Objective To evaluate the effect of sirolimus-eluting stent implantation on the reendothelialization of abdominal aorta in rabbits, and to compare it with that of bare-metal stent implantation. Methods Twenty-four New Zealand male rabbits were randomly and equally divided into two groups after hyperlipemia feeding. Sirolimus-eluting stent, Firebird, or bare-metal stent, Mustang, was implanted in the abdominal aorta in two groups. Every three experimental rabbits from both groups were sacrificed each time at 3, 7, 14 and 28 days after the procedure, and the specimens of aorta were harvested and processed for observing the vascular endothelia with scanning electron microscopy, and the degree of re-endothelialization was analyzed bY computed imaging analysis technique. Results Three＇ days after the procedure, in both groups neogenetic endothelia could be hardly seen in the treated aorta although inflammatory reaction was rather obvious. At the time of 7, 14 and 28 days after the operation, the covering rate of re-endothelialization in sirolimus-eluting stent group was significantly lower than that in bare-metal stent group （ 15% ± 8% vs 53% ± 9%, 49%± 16% vs 83% ± 4% and 73% ± 3% vs 93% ± 4% respectively, P 〈 0.05）. Conclusion Compared with bare-metal stent, sirolimus-e]uting stent will markedly delay the re-endothelialization of the implanted vessels.
出处
《介入放射学杂志》
CSCD
北大核心
2009年第8期616-619,共4页
Journal of Interventional Radiology
关键词
再内皮化
雷帕霉素洗脱支架
裸支架
re-endothelialization
sirolimus-eluting stent
bare-metal stent
