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2型糖尿病合并非酒精性脂肪肝患者血清脂联素与胰岛素抵抗研究 被引量:1

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摘要 目的分析2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)患者血清脂联素与胰岛素抵抗关系。方法测定2型糖尿病105例,其中合并NAFLD者73例,及正常对照组30例的脂联素、BMI、HOMA-IR等指标。结果T2DM合并重度NAFL组BMI、WHR、FINS、TG、VLDL、HOMA-IR均较T2DM无NAFL组显著增高(P〈0.0l或P〈0.05);T2DM合并重度NAFL组BMI、WHR、FINS、HOMA.IR均较T2DM合并轻度NAFL组显著增高(P〈0.01或P〈0.05)。T2DM合并重度NAFL组血清脂联素水平显著低于他DM无NAFL组与T2DM合并轻度NAFL组(P〈0.01或P〈0.05)。Logistic逐步回归分析显示BMI、TG、脂联素、HO-MA-IR与T2DM合并NAFL密切相关(13=0.225,0.385,-0.548,0.421,P〈0.05)。结论2型糖尿病合并非酒精性脂肪肝以胰岛素抵抗为基础,脂联素与NAFL密切相关。
出处 《中国医师杂志》 CAS 2009年第8期1130-1131,共2页 Journal of Chinese Physician
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