摘要
目的研究芍药苷的抗抑郁作用,并对其作用机制进行初步探讨。方法采用小鼠强迫游泳、小鼠悬尾实验和体外培养PC12细胞的方法,观察芍药苷对小鼠游泳不动时间、悬尾不动时间的影响以及对皮质酮损伤PC12细胞存活率的影响。结果芍药苷连续给药一周后,能明显缩短小鼠在行为学实验中的不动状态时间,并能拮抗皮质酮诱导的神经毒作用,提高PC12细胞的存活率。结论芍药苷具有明显的抗抑郁作用,其机制可能与细胞保护作用有关。
Objective To investigate the antidepressant-like effects and mechanisms of paeoniflorin. Methods The antidepressant effects were evaluated by tail suspension test （TST） and forced swimming tests （FST） in mice. PC12 cells neurotoxicity injury was induced by corticosterone and the cell viability were measured by MTT assay. Results The research results indicated that one week of chronic administration paeoniflorin （100, 200 mg/kg） could significantly reduce the duration of immobility in both FST and TST. Paeoniflorin at increasing doses （2-10 μmol/L） protected mice against the corticosterone-induced toxicity in PC12 cells in a dose-dependent manner. Conclusion The present study indicates that paeoniflorin has remarkable antidevressant function, which mav be related with its cell protection activities.
出处
《现代药物与临床》
CAS
2009年第4期231-233,共3页
Drugs & Clinic
关键词
芍药苷
抗抑郁
皮质酮
PC12细胞
paeoniflorin antidepressant
corticosterone PC12 cells
