摘要
目的：探讨粒－巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ）对儿童恶性肿瘤化疗的影响和临床应用价值。方法：３４例３８例次肿瘤化疗后粒细胞缺乏患者，用ＧＭ－ＣＳＦ２～５μｇ／ｋｇｄ－１，３～５ｄ，观察中性粒细胞回升、发热、口腔溃疡等情况。结果：用ＧＭ－ＣＳＦ疗效明显，与对照组比较，中性粒细胞升至≥１．５×１０９／Ｌ提前了８．３ｄ，发热和口腔溃疡减少了３３％、２８％，输血或成分输血减少２．４次。
Objective:To explore the effect and clinical value of granulocyte macrophage colony stimulating factor (GM CSF) on chemotherapy for the children malignant tumor Methods: GM CSF was used to treat 34 cases (38 times) of patients with granulocytopenia after chemotherapy for the malignant tumor They were given GM CSF 2￣5 μg/kg·d -1 for 3￣5 days,and the conditions of the granulocytes ,fever and oral ulcer were observed Results: The effect on the patients after using GM CSF was remarkable In comparison with the control group, the recovery time for granulocytes (≥1 5×10 9/L) was advanced 8 3 days, frequencies of fever and oral ulcer were downed 33% and 28%, blood or component blood transfussion was reduced 2 4 times, respectively Conclusion: The risk and complication can be significantly reduced after chemotherapy for the children malignant tumor by using GM CSF
出处
《广西医科大学学报》
CAS
1998年第3期72-74,共3页
Journal of Guangxi Medical University
关键词
恶性肿瘤
药物疗法
儿童
GM-CSF
granulocyte macrophage colony stimulating factor
chemotherapy
malignant tumor
