摘要
目的研究儿童白血病深部真菌感染的临床特征及治疗效果。方法对５０例急性白血病实施强烈化疗，可疑病人作真菌培养等检查，并提出深部真菌感染的诊断方法及疗效标准，对确诊深部真菌感染的病例以氟康唑治疗，并采取积极的支持治疗及抗生素预防治疗。结果５０例患者中２１例２２例次发生深部真菌感染，全部病例均有严重的骨髓抑制及高热，予氟康唑治疗，治愈率８６．４％，无明显毒副作用；深部真菌感染的发生与粒细胞减少程度以及持续时间有关，与疾病的种类无关，Ｐ＞０．０５；缓解前的诱导治疗较缓解后的巩固强化治疗易发生深部真菌感染，Ｐ＜０．０１。结论中性粒细胞严重减少的病人易发生深部真菌感染，诱导治疗阶段尤为多见。
Objective To investigate the clinic characteristics of deep fungal infection and effect of treatment.Methods A clinical trial was conducted with 50 childhood acute leukemia undergoing intensified chemotherapy,laboratory examination such as fungal culture and smear were made for suspected patients,diagnostic methods and effective criteria were proposed.Patients with deep fungal infection were treated with fluconzole,supportive treatment and antibacteria prophylaxis were used.Result 21 of 50 patients were confirmed to have deep fungal infection,all patients have neutropenia and fever,86.4% was cured with fluconzole,not obvious side effect was observed.Deep fungal infection was related to neutropenia and its prolonged duration,it was more likely to occur in induce chemotherapy than intensified chemotherapy (P<0.01).Conclusion It is suggested that deep fungal infection is a frequent complication.in patients with severe neutropenia,fluconazole is effective for deep fungal infection.
出处
《铁道医学》
1998年第4期230-232,共3页
Railway Medical Journal
