摘要
目的研究杏仁核在睡眠—觉醒调节中的作用。方法多导睡眠描记术（ＰＳＧ）和杏仁核微量注射。结果Ｌ－谷氨酸引起觉醒（Ｗ）增多、慢波睡眠（ＳＷＳ）和总睡眠时间（ＴＳＴ）减少；注射海人酸后第１天引起失眠，第３天后Ｗ减少，ＳＷＳ和ＴＳＴ增多，而快波睡眠无显著变化。结论兴奋杏仁核神经元胞体可引起睡眠抑制，而损毁杏仁核神经元胞体则引起ＳＷＳ增多。
Objective To investigate the role of nucleus amygdalae in regulating sleep and wakefulness. Method Polysomnography(PSG) and nucleus amygdalae microinjection. Results L-glutamate(L-Glu) enhanced wakefulness(W), but decreased slow wave sleep(SWS) and total sleep time(TST). Bilateral injection of kainic acid(KA) resulted in biphasic effects. At the first day after KA, insomnia occured. However, SWS and TST increased and W decreased since the third day, but PS did not change significantly. Conclusions The excitation of the cell bodies of neurons in nucleus amygdalae induces a SWSinhibiting effects, but the destruction of nucleus amygadalae increases SWS.
出处
《安徽医科大学学报》
CAS
1998年第4期253-254,共2页
Acta Universitatis Medicinalis Anhui
基金
安徽省自然科学基金
关键词
杏仁核
谷氨酸
睡眠
沉醒
海人酸
大鼠
amygdaloid body/durg eff
glutamic acid/pharmacol
kainic acid/pharmacol
sleep/drug eff
arousal/drug eff
