摘要
核因子κB是一种多功能核转录因子，能调节多种参与炎症免疫反应的细胞因子、炎症介质、黏附分子及蛋白酶类的基因转录过程，从而控制它们的生物合成。肺动脉高压是临床常见的病理生理过程，致病的原因有很多，但慢性阻塞性肺疾病（chronic obstructive pulmonaryd isease，COPD）是最常见的病因。COPD是一种以气道气流受限且不完全可逆为特征的疾病，气道炎症是COPD重要病理基础，而且在肺血管重构中有很重要的作用，肺血管重构进一步导致COPD继发肺动脉高压。通过阐述核因子κB、COPD气道炎症、肺血管重构之间相互作用的机制，可以对COPD继发的肺动脉高压的治疗提供新的思路和方法。
Nuclear factor-kappaB is a multi purpose nuclear transcription factor,which has the ability of adjusting to participate in a variety of inflammatory cytokines in the immune response, inflammatory mediators,and adhesion molecules such as gene-transcription process and thus control their biosynthesis. Pulmonary hypertension is a common pathophysiology course in clinic. There are many reasons of pathogenesis,but chronic obstructive pulmonary disease（COPD） is the most common cause. COPD is a disease that is characterised by airflow limitation of peripheral airways, which is not fully reversible and progressive. Airway inflammation is an important pathological basis of COPD,which plays an important role in pulmonary vascular reconstruction. Pulmonary vascular reconstruction can further lead to pulmonary hypertension caused by COPD. Through explaining the interaction among nuclear factor-kappaB, COPD airway inflammation and pulmonary vascular remodeling, new ideas and methods can be bred for the treatment of pulmonary hypertension caused by COPD.
出处
《国际呼吸杂志》
2009年第6期375-379,共5页
International Journal of Respiration
关键词
核因子ΚB
肺动脉高压
慢性阻塞性肺疾病
肺血管重构
气道炎症
Nuclear facto-kappaB
Pulmonary hypertension
Chronic obstructive pulmonary disease
Pulmonary vascular remodeling
Airway inflammation
