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氨磷汀在接受化疗的老年恶性血液病患者中应用安全性的比较研究

Safety of amifostine in elderly hematologic malignancies patients receiving chemotherapy:a comparative study
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摘要 目的评估氨磷汀在接受化疗的老年恶性血液病患者中应用的安全性。方法采用回顾性分析方法对年龄≥60岁(组1)和<60岁(组2)的接受化疗的恶性血液病患者应用氨磷汀的副作用进行比较,了解在老年患者中应用的安全性。结果暂时性低血压为最常见的副作用,收缩压下降>20mmHg在两组中发生率相当(分别为27.1%和28.8%,P>0.05)。恶心和呕吐为第二大副作用,其发生率在组1中为10%,组2为20.8%(P<0.05)。其它主观症状发生率两组相当。结论氨磷汀在接受化疗的老年恶性血液病患者中应用是安全的,无明显副作用。 OBJECTIVE In order to evaluate the safety of amifostine in elderly hematologic malignancies patients receiving chemotherapy. METHODS The side effects of amifostine were compared in patients ≥60 years (group Ⅰ ) and patients 〈 60 years(group Ⅱ ) by retrospective study. RESULTS Transient hypotension was the most common side effect. Decreases in systolic blood pressure 〉20mmHg were of similar frequency in both groups (27.1% vs 28.8%, P 〉0.05).Patients in group Ⅱ more often suffered from nausea/vomiting than in group Ⅰ (20.8% vs 10.0%, P 〈 0.05) .Other subjective groups.CONCLUSION Amifostine was administed symptoms occurred with similar frequency in both in elderly hematologic malignancies patients receiving chemotherapy was safety.
出处 《海峡药学》 2009年第8期101-102,共2页 Strait Pharmaceutical Journal
关键词 氨磷汀 恶性血液病 老年人 化疗 Amifostine Hematologic malignancies Elderly Chemotherapy
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参考文献4

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