摘要
目的探讨血管内皮生长因子(VEGF)和肿瘤坏死因子-α(TNF-α)在乳腺癌患者外周血中表达水平的变化及临床意义。方法应用酶联免疫吸附法检测62例乳腺癌(乳腺癌组)和52例乳腺良性肿瘤患者(乳腺良性病组)的VEGF水平,并以50例健康志愿者(对照组)为对照;再用放射免疫分析法测出各组的TNF-α值。结果乳腺癌组外周血清VEGF、TNF-α水平明显高于乳腺良性病组和对照组,且乳腺癌组各临床分期间外周血清的VEGF和TNF-α水平差异有统计学意义(P均<0.05)。结论血清VEGF和TNF-α水平可能与乳腺癌的发生发展有一定的关系,检测其表达水平的变化对乳腺肿瘤的早期诊断和判断患者病情变化及预后有一定的参考价值。
Objective To investigate the expression of serum vascular endothelial growth factor（VEGF） and tumor necrosis factor-α （TNF-α） in breast cancer and its clinical significance. Methods Enzyme linked immunosorbent assay（ELISA） was used to detect the levels of serum VEGF in 62 patients with breast cancer,52 patients with benign breast tumor and 50 healthy subjects, and the serum levels of TNF-α were detected by RIA method for the three groups. Results The levels of serum VEGF and TNFoa in patients with breast cancer were significantly higher than those in healthy subjects and the patients with benign breast tumor. The levels of serum VEGF and TNF-α were correlated with clinical stage （ P 〈 0. 05）. Conclusion The levels of serum VEGF and TNF-α may be correlated with the genesis and development of breast cancer, and the detection of the levels of serum VEGF and TNF-α may play an important role in the diagnosis of breast cancer and the evaluation for patients＇ condition and prognosis.
出处
《河北医药》
CAS
2009年第18期2377-2378,共2页
Hebei Medical Journal
基金
邯郸市科学技术研究与发展计划项目(编号:20072817059-3)
关键词
乳腺肿瘤
VEGF
肿瘤坏死因子-Α
breast cancinoma
vascular endothelial growth factor
tumor necrosis factor-α
