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乙型肝炎病毒耐药突变位点及机制 被引量:9

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作者 雷君 唐红
出处 《肝脏》 2009年第4期342-345,共4页 Chinese Hepatology
基金 国家重点基础研究发展973计划 NO.2007CB512902 2006CB504302
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参考文献20

  • 1Zoulim F. Mechanismof viral persistence and resistance to nueleoside and nucleotide analogs in chronic hepatitis B virus infection. Antiviral Res, 2004, 64:1-15.
  • 2Chen JY, Wang LW, Sun XM, et al. Effects of HBV gene variati ons on disease development and antivira| therapy for patients with chronic hepatitis B. Hepat obiliary PancreatDis lnt, 2005, 4: 393- 397.
  • 3Marc G, Liang TJ. Drug Targets and Molecular Mechanisms of Drug Resistance in Chronic Hepatitis B. Gastroenterology, 2007, 132 : 1574-1585.
  • 4Barthotomeusz A, Loearnini SA, Ayres A, et al. Mechanistic basis for hepatitis B virus resistance to acyclie nueleoside phosphonate analogues, Adefovir and Tenofovir. Hepatology, 2005,42, 594A.
  • 5Westland CE, Yang H, Delaney WE, et al. Activity of adefovir dipivoxil against all patterns of lamivudine-resistant hepatitis B viruses in patients. J Viral Hepat, 2005,12: 67-73.
  • 6赵卫峰,邵幼林,甘建和,陈良云,朱义玲,毛日成,张继明.拉米夫定耐药HBV毒株RT区变异分析[J].中国实用内科杂志,2008,28(2):119-121. 被引量:13
  • 7Borroto-Esoda K, Miller MD, Arterburn S. Metaanalysis across adefovir clinical trials demonstrates the absence of novel adefovir-associated mutations and eonfirms the role of the rtA181V and rtA236T mutations in HBV polymerase with virologic failure. Hepatology, 2006,44 : 552A.
  • 8Schildgen O, Sirma H. Variant of Hepatitis B Virus with Primary Resistance to Adefovir. N Engl J Med, 2006,354:17.
  • 9Bartholomeusz A, Locarnini SA. Antiviral drug resistance: clinical consequences and molecular aspects. Semin Liver Dis, 2006,26: 162-170.
  • 10Locarnini S, Qi X, Arerburn S, et al. Incidence and predictors of emergence of adefovir resistant HBV during four years of adefovir dipivoxil (ADV therapy for patients with chronic hepatitis B (CHB). J Hepatol,2005,42:A36.

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