摘要
运用大鼠乙酸慢性胃溃疡模型采用中药健脾益气方,观察治疗7d及21d后溃疡指数,溃疡抑制率及血清脂质过氧化物（LPO）和NO_3^-/NO_2^-含量变化。结果显示:中药治疗组溃疡指数、血清LPO含量显著低于模型组（P<0.01 ）,溃疡抑制率及血清NO_3^-/NO_2^-含量显著高于模型组（P<0.01 ）,与雷尼替丁组相比溃疡指数、血清LPO含量无统计学差异,但溃疡抑制率及血清NO_3^-/NO_2^-含量高于雷尼特丁组。模型组溃疡指数、血清LPO含量显著高于正常对照组（P<0.01 ）。而血清NO_3^-/NO_2^-含量则低于正常对照组（P<0.01）。提示中药健脾益气方能明显促进乙酸慢性胃溃疡愈合,其疗效与抑制脂质过氧化反应,诱导或提高血清NO合成有关。说明健脾益气方有胃粘膜保护作用。
This study aimed at investigating the effect of Jianpiyiqi Preparation (JPYQ) on chronic peptic ulcer, using a rat model caused by acetic acid. After 7 days and 21 days of treatment, animals were killed, indexes of peptic ulcer, rates of peptic ulcer controlled and the level of lipid peroxide(LPO) and NO3-/NO2- in serum were observed. The results showed that indexes of ulcer and LPO in serum of JPYQ group were decreased and the level of NO3-/NO2- was increased as compared with those of model group (P<0.01), the rates of the ulcer controlled and the level of NO3-/NO2- were higher than those of ranitidine group (P<0. 01). The indexes of ulcer and the level of LPO of model group were increased and the level of NO3- /NO2-was decreased as compared with control group. The result suggests that JPVQ promotes the healing of peptic ulcer. Its mechanism is related with decreased LPO and increased nitric oxide (NO), which shows that JPYQ protects gastric mucosa.
出处
《同济医科大学学报》
CSCD
1998年第2期152-155,共4页
Acta Universitatis Medicinae Tongji
基金
国家中医药管理局资助项目(No.95B151)
关键词
胃溃疡
中医药疗法
健脾益气方
peptic ulcer
acetic acid
Jianpiyiqi preparation
nitric oxide
lipid peroxide
