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水相合成CdX(X=Te,Te/CdS,Te/ZnS)红色量子点及毒性效应 被引量：4

Aqueous Phase Synthesis of Red CdX(X=Te,Te/CdS,Te/ZnS) Quantum Dots and Their Toxic Effects
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摘要 分别以巯基乙酸(Mercaptoacetic Acid,MA)、还原型谷胱甘肽(Glutathione,GSH)为稳定剂在水相中直接合成了巯基乙酸CdTe(CdTe-MA)、红色巯基乙酸CdTe/CdS(CdTe/CdS-MA)、巯基乙酸CdTe/ZnS(CdTe/ZnS-MA)及谷胱甘肽CdTe(CdTe-GSH)量子点.其中,CdTe-GSH量子点的量子产率可达47.3%.体外溶血实验证实CdTe/ZnS-MA和CdTe-GSH量子点的溶血率较CdTe-MA和CdTe/CdS-MA低,浓度为0.05mmol/L的量子点溶血率<5%,达到了生物医用材料的要求.活体实验证实:通过尾静脉方式把量子点注入小鼠体内后,荧光显微镜观察发现高剂量的量子点(0.4mmol/10g)在体内主要在心、肝、脾、肾组织中分布较多,且引起不同程度的组织病变. Mercaptoacetic acid （MA） capped CdTe, CdTe/CdS, CdTe/ZnS quantum dots （QD） and glutathione （GSH）-capped CdTe QDs were directly synthesized in aqueous media. The fabricated CdTe-GSH QDs have an ultra small hydrodynamic diameter （3--4 nm） and possess high quantum yields （47.3%）. In vitro hemolysis testing showed that the hemolysis rates （HR） of CdTe/ZnS-MA and CdTe-GSH were less than 5% （concentration being 0.05 mmol/L）, which were lower than CdTe-MA and CdTe/CdS-MA QDs, meeting the requirements for biomedical materials. The toxicity of QD in vivo was tested by injected QD in mice through tail vein. Fluorescence microscopy showed that a high dosage （0.4 mmol/10 g） of CdTe-GSH and CdTe/ZnS-MA QD was distributed mainly in the heart, liver, spleen and kidney tissues and caused varying degrees of tissue lesions.
作者 王显祥 黄娟 靳茹文 杨中科 单志 杨婉身
机构地区 四川农业大学生命科学与理学院 四川大学化学学院 四川农业大学动物医学院
出处 《化学学报》 SCIE CAS CSCD 北大核心 2009年第17期2025-2030,共6页 Acta Chimica Sinica
基金 四川农业大学引进人才基金(No.007202) 四川省教育厅自然科学科研重点(No.2005A033)资助项目
关键词 红色量子点 溶血 毒性 谷胱甘肽 red quantum dot hemolysis toxicity glutathione
分类号 O614.242 [理学—无机化学]
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参考文献20

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共引文献23

同被引文献153

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引证文献4

二级引证文献16

化学学报
2009年 第17期

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