摘要
以１－甲基－３－乙基（－４－氯）－５－吡唑甲酰肼作原料，经两步得到４－氨基－３－（１－甲基－３－乙基（－４－氯）－５－吡唑基）－１，２，４－三唑－５－硫酮（３），３再与取代羧酸反应，得到一系列３－（１－甲基－３－乙基（－４－氯）－５－吡唑基）－６－取代均三唑并［３，４－ｂ］－１，３，４－噻二唑（４、５、６）．元素分析、１ＨＮＭＲ、ＩＲ和ＭＳ确定了它们的结构．初步生测结果表明：３具有植物生长调节活性，４ｂ、４ｄ、６具有杀菌活性．
In view of the biological activity of s triazolo 1,3,4 thiadiazole fused heterocyclic derivatives, nine novel compounds 3 ((4 chloro) 3 ethyl 1 methyl 5 pyrazolyl) 6 substituted s triazolo 1,3,4 thiadiazoles (4a￣g,5,6) were synthesized by condensation of carboxylic acid with 4 amino 3 ((4 chloro) 3 ethyl 1 methyl 5 pyrazolyl) 1,2,4 triazole 5 thione. Their structures were characterized by elemental analysis, 1H NMR , IR and MS spectroscopy. The preliminary bioassay tests showed that compound 3 exhibited plant growth regulation activity and 4b, 4d and 6 possessed moderate fungicidal activity .
出处
《应用化学》
CAS
CSCD
北大核心
1998年第3期59-62,共4页
Chinese Journal of Applied Chemistry
关键词
均三唑
并噻唑
合成
生物活性
吡唑基
pyrazolyl s triazolo 1,3,4 thiadiazole,synthesis,bioassay
