摘要
目的探讨高血压病史对老年人脑血流动力学的影响。方法选择卒中队列研究人群中年龄65～80岁人群2321例,以基线调查时有无高血压病史分为病例组(1168例)和对照组(1153例)。比较两组颈动脉血流动力学指标和积分的差异,描述其分布特征。结果脑血管血流动力学积分值病例组为59.61±31.68,对照组为80.73±25.30,两组积分值异常(<75分)率分别为59.5%和30.3%(P<0.01)。病例组血流运动学各指标显著低于对照组,血流动力学各指标显著高于对照组,心脏病、肥胖、卒中家族史等危险因素的暴露率也显著高于对照组(P<0.01)。结论高血压病史对老年人脑血管血流动力学有显著影响,可导致脑卒中风险明显增加。
Objective To probe into the influence of hypertension history to cerebrovascular hemodynamic parameters in elderly. Methods 2 321 individuals aged 65 - 80 year were selected from a cohort. Participants were divided into 2 groups according to hypertension history in baseline. 1 168 cases with history of hypertension were defined as hypertension case group and 1 153 cases without history of hypertension were defined as control group. Differences and distribution of cerebrovascular hemodynamic parameters between 2 groups were compared. Results The cerebrovaseular hemodynamie parameters synthesized scores in case and control groups were 59. 61 ± 31.68 and 80. 73 ± 25.30 （ P 〈 0. 01 ）. The abnormal rates of the score （ 〈 75 points ） in 2 groups were 59. 5 % and 30. 3 % （P 〈 0. 01 ）. Kinematic parameters in case group were significantly lower than those in control group. However, dynamic parameters as well as exposure rates of history of heart disease, obese and family history of stroke in case group were significantly higher than those in control group （P 〈 0.01 ）. Conclusions There is significant influence of hypertension history to cerebrovascular hemodynamie in elderly and it may increase the risk of stroke.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2009年第17期2145-2147,共3页
Chinese Journal of Gerontology
基金
国家十五攻关滚动项目(2004BA703B12)
上海市科委重大项目(03DZ19701)
