期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肥胖症全基因组关联分析研究进展 被引量：3

Research progress on obesity by genome-wide association study
下载PDF
导出
摘要 肥胖症的产生是由遗传和各种环境因素相互作用的结果。肥胖易感基因可以为肥胖症机制的研究提供重要的视角。全基因组关联分析(GWAS)的出现为研究肥胖易感基因提供了重要的途径。GWAS近来已经发现与肥胖强烈相关的新的遗传学因素,如脂肪含量和肥胖相关基因(FTO),胰岛素诱导基因2(INSIG2),血小板型磷酸果糖激酶(PFKP)等。目前,通过GWAS发现的一些肥胖易感基因还存在着争议,有待更多具有统计效能的重复性试验来证实。 Obesity is the result of the interaction between genetic and environmental factors. Susceptive genes of obesity can provide important insights into the mechanism underlying this condition. The advent of genomewide association study （GWAS） provides an important approach for studying susceptive genes of obesity. GWAS has recently identified some novel genetic factors with strong associations with obesity, such as FTO （the fat mass and obesity associated gene ）, INSIG2 （insulin induced gene 2）, PFKP （platelet type phosphofructokinase） and so on. At present, some of them are still controversial, so it is essential to perform more statistically powered replications of GWAS findings.
作者 石娟 洪洁
机构地区 上海交通大学医学院附属瑞金医院内分泌代谢病科 上海市内分泌代谢病临床中心
出处 《国际内科学杂志》 CAS 2009年第9期544-547,共4页 International Journal of Internal Medicine
关键词 肥胖 全基因组关联分析 基因多态性 Obesity Genome-wide association study Gene polymorphism
分类号 R58 [医药卫生—内分泌]
  • 相关文献

二级参考文献32

  • 1智联腾,周钢桥,贺福初.人类复杂疾病关联研究中群体分层的检出和校正[J].遗传,2007,29(1):3-7. 被引量：6
  • 2Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, Henning AK, SanGiovanni JP, Mane SM, Mayne ST, Bracken MB, Ferris FL, Ott J, Barnstable C, Hoh J. Complement factor H polymorphism in age-related macular degeneration. Science, 2005, 308(5720): 385-389.
  • 3Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie K, Lyon H, Hirschhorn JN, Laird NM, Lenburg ME, Lange C, Christman MF. A common genetic variant is associated with adult and childhood obesity. Science, 2006, 312(5771): 279-283.
  • 4Rosskopf D, Bornhorst A, Rimmbach C, Schwahn C, Kayser A, Kruger A, Tessmann G, Geissler I, Kroemer HK, Volzke H. Comment on "A common genetic variant is associated with adult and childhood obesity". Science, 2007, 315(5809): 187: author reply 187.
  • 5Frayling TM, Timpson N J, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, EUard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham N J, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 2007, 316(5826): 889-894.
  • 6Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix J J, Kathiresan S, Hirschhorn JN, Daly M J, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC,Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Bostrom K, Isomaa B, Let- tre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Rastam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E,Sjogren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science, 2007, 316(5829): 1331-1336.
  • 7Ubeda M, Rukstalis JM, Habener JF. Inhibition of cyclindependent kinase 5 activity protects pancreatic beta cells from glucotoxicity. J Biol Chem, 2006, 281 (39): 28858-28864.
  • 8Foley AC, Mercola M. Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex. Genes Dev, 2005, 19(3): 387-396.
  • 9Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, Konig IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien E Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas E Tobin MD, Ziegler A, Thompson JR, Schunkert H. Genomewide association analysis of coronary artery disease. N Engl J Med, 2007, 357(5): 443-453.
  • 10Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet, 1993, 52(3): 506-516.

共引文献52

同被引文献31

引证文献3

二级引证文献12

国际内科学杂志
2009年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部