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舌癌组织中P53和血管内皮生长因子的表达及其与肿瘤血管形成的关系 被引量：1

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摘要 新生血管形成是肿瘤生长和转移的基础，血管内皮生长因子（vEGF）能刺激血管内皮细胞增殖，对肿瘤血管形成有重要作用。Mukhopadhyay等和Fontanini等认为、p53基因突变可通过调控VEGF的表达水平来影响肿瘤血管的形成。为了解突变型P53、VEGF和肿瘤内微血管密度（intratumoral microvessel density，IMVD）相互关系及其临床意义．我们采用免疫组织化学方法对50例舌癌组织的p53、VEGF进行检测．并用CD34抗体标记肿瘤组织血管内皮细胞，计算IMVD。
作者 黄玉娥 张秀清
机构地区 第四军医大学口腔医学院 山西省临汾市人民医院肿瘤科
出处 《中国药物与临床》 CAS 2009年第9期822-824,共3页 Chinese Remedies & Clinics
关键词 血管内皮生长因子 肿瘤血管形成 突变型P53 舌癌组织 血管内皮细胞增殖 P53基因突变 肿瘤内微血管密度 免疫组织化学方法
分类号 R739.8 [医药卫生—肿瘤]
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参考文献11

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同被引文献15

  • 1李颖,陈平,段世刚.CD105 mRNA在原发性肝细胞癌的表达与术后复发的关系[J].中华消化外科杂志,2007,6(1):48-51. 被引量：4
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  • 3Li C, Gardy R, Seon BK, et al. Both high intratumora microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cance patients correlate with poor prognosis. Br J Cancer, 2003, 88(9) : 1424.
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  • 6Wang X, Hershman DL, Abrams JA, et al. Predictors of survival after hepatic resection among patients with colorectal liver metastasis. Br J Cancer, 2007, 97(12):1606-1612.
  • 7Li C, Guo B, Wilson PB, et al. Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer. Int J Caneer, 2000,89(2) :122-126.
  • 8Svagzdys S, Lesauskaite V, Pavalkis D, et al. Microvessel density as new prognostic marker after radiotherapy in rectal cancer. BMC Cancer,2009, 26(9) :95.
  • 9张江宇,王颀,朱彩霞,李文萍,张雅洁,张佳立,陈中扬,陈文静.CD105在乳腺癌发生发展过程中表达的研究[J].中华肿瘤防治杂志,2007,14(19):1472-1474. 被引量：6
  • 10牛保华,皇甫超申,赵卫.CD105及微血管密度与胃癌的关系[J].河南大学学报（医学版）,2008,27(2):24-25. 被引量：6

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中国药物与临床
2009年 第9期

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