摘要
采用三氯氧磷/Py或DCC/Py为脱水体系,N-苄氧甲酰基氨基酸和取代苯酚缩合生成了4种N-苄氧甲酰基氨基酸芳基酯,发现以三氯氧磷/Py为脱水剂的反应产率比以DCC/Py为脱水剂的反应产率高,产率为81.9%～87.7%.产物的结构用1HNMR、13CNMR与IR进行了表征.初步研究了目标化合物的杀虫和杀菌活性,结果表明杀菌活性高于杀虫活性.图1,表1,参9.
Four aryl esters of N-benzyloxy-formoyl-amino acids were synthesized by condensation reactions of N-benzyloxy-formoyl-amino acids with substituted phenols in the presence of phosphorus oxychloride / Py system or DCC / Py system. It was found the yields of the reactions in the first system were higher than those in the second system. The structures of the target compounds were characterized by 1HNMR, 13CNMR and IR. It was investigated the biological activity of the title compounds, the results show their bactericidal activity is higher than the insecticidal activity, lfig., ltab., 9refs.
出处
《湖南科技大学学报（自然科学版）》
CAS
北大核心
2009年第3期96-99,共4页
Journal of Hunan University of Science And Technology：Natural Science Edition
基金
教育部留学回国人员科研启动基金资助项目([2007]1108)
湖南省自然科学基金(06JJ50016)
湖南省教育厅资助项目(07C288)
湖南科技大学博士启动基金(E55105)
关键词
氨基酸芳基酯
三氯氧磷
吡啶
合成
生物活性
amino acid aryl ester
phosphorus oxychloride
pyridine
synthesis
biological activity
