摘要
急性前髓细胞性白血病或急性早幼粒细胞白血病(APL)是一种特殊类型的血液系统恶性克隆性疾病,其特点是异常早幼粒细胞无限增殖伴分化受阻,是白血病中最危重的一种类型。95%以上的APL患者具有(t15;17)染色体异常,形成PML/RAR融合基因,几乎存在于所有的APL细胞中,成为APL细胞的一个特异性标志,是APL发病重要分子基础。自从全反式维甲酸(ATRA)成功用于临床诱导APL分化以来,对诱导分化剂的作用机制的研究已取得很大的进展。本文主要对APL细胞遗传学和分子生物学特征、发病机制、诱导分化机制、分化后细胞表型变化等方面对APL细胞诱导分化实验的研究进展进行综述。
Acute Promyelocytic Leukemia is a special malignant clone disease in hematological system, which is the most dan- ger in leukenia, which characterized by abnormal promyelocyte infinite multiplication and stopped differentiation. Above 95% of APL patients have t （15;17） chromosomal abnormality, forming PML/RARoL fusion gene, which almost in all APL cell, to become a special sign in APL cell and an important molecular basis in invasion of APL. Since ATRA has successfully used in clinic induction of APL dif- ferentiation, make great advancement in action of differentiated agt. This article reviewed thecell genetics and molecular biology charac- teristic of APL, pathogenesy, induction and differentiated pathogenesy, the changed differentiation cell phenotype and other research advancements in induced differentiation experiment of APL.
出处
《现代生物医学进展》
CAS
2009年第15期2960-2964,共5页
Progress in Modern Biomedicine
关键词
急性前髓细胞性白血病
分化
Acute Promyelocytic Leukemia
Differentiate
