摘要
HBV的抗病毒治疗目标是使HBeAg发生血清学转换和病毒复制的持续抑制。多项研究表明HBV的定量检测在决定治疗时机、减少治疗失败和监测耐药性方面发挥着重要作用。WHO建立了统一的标准品，以IU／ml（国内文献用U／ml）表示HBVDNA的含量。HBsAg和HBeAg在预测血清学转换中可能发挥着潜在作用。本文探讨了HBV病毒学和血清学标志物的监测及其在临床中的应用前景。
Antiviral treatment of chronic hepatitis B is aimed at HBeAg seroconversion and inhibition of HBV viral replication. A lot of evidences showed that quantification of hepatitis B virus play an important role in timing selection of treatment initiation, treatment failure evaluation, and screening of resistance. International units per ml （IU/ml） are used to express results for HBV DNA quantification by WHO. HBsAg and HBeAg are potentially useful to predict HBeAg seroconversion. This review discusses the prospective application of detection of HBV virological and serological markers, and their use in clinic.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2009年第9期967-970,共4页
Chinese Journal of Laboratory Medicine
