摘要
目的观察阴阳透刺法对急性脑梗死患者的组织型纤溶酶原激活剂(t-PA)、其抑制物组织型纤溶酶原激活物抑制剂(PAI-1)的影响,探讨针刺治疗缺血性脑血管病可能的作用机制。方法将80例急性脑梗死患者分为治疗组和对照组各40例。分别观察治疗前、治疗后血浆t-PA、PAI-1的活性,并与正常组40例进行对照。结果治疗前,两组t-PA的活性较明显低下,相反,PAI-1的活性明显增高,与正常组比较差异有统计学意义(P<0.01)。治疗后,两组t-PA的活性各与其自身治疗前比较明显增强,而PAI-1活性各与其自身治疗前比较明显降低(P<0.01,P<0.05),且治疗后两组间t-PA及PAI-1活性比较差异有统计学意义(P<0.05)。结论治疗前,急性脑梗死患者t-PA活性明显低下和PAI-1活性明显增高,阴阳透刺法可降低PAI-1活性和增高t-PA活性,调节纤溶功能,促进溶解血栓,确为临床针刺治疗急性脑梗死的一种较可靠治疗方法。
Objective To investigate the possible mechanism of therapeutic action of acupuncture on ischemic cerebrovascular disease by observing the influence of yin-yang Penetration needling method on tissue type plasminogen activator （t-PA） and a substance that inhibits it, tissue type plasminogen activator inhibitor （PAI-1） in patients with acute cerebral infarction. Methods Eighty patients with acute cerebral infarction were randomly allocated to treatment and control groups, 40 cases each. Plasma t-PA and PAI-1 activities were examined in the two groups before and after treatment and compared with those in a normal group of 40 cases. Results Before treatment, t-PA activity decreased obviously but PAI-1 activity increased obviously in the two groups. There were statistically significant differences compared with the normal group （P〈0.01）. After treatment, t-PA activity increased obviously but PAI-1 activity decreased obviously in the two groups compared with those in their respective groups before treatment. There were statistically significant pre-/post-treatment differences （P〈0.01,P〈0.05）. Posttreatment t-PA and PAI-1 activities had statistically significant differences between the two groups （P〈0.05）. Conclusion Before treatment, t-PA activity decreased obviously but PAI- 1 activity increased obviously in patients with acute cerebral infarction. Yin-yang Penetration needling method can decrease PAI-1 activity, increase t-PA activity and promote thrombolysis. It is exactly a more reliable method of acupuncture for treating acute cerebral infarction clinically.
出处
《上海针灸杂志》
2009年第9期504-506,共3页
Shanghai Journal of Acupuncture and Moxibustion
关键词
针刺
透刺
脑梗死
组织型纤溶酶原激活剂
组织型纤溶酶原激活物抑制剂
Acupuncture
Penetration needling method
Cerebral infarction
Tissue type plasminogen activator
Tissue type plasminogen activator inhibitor
