摘要
目的观察紫茜抗癌胶囊的急性毒性反应。方法给实验小鼠灌服不同浓度的紫茜抗癌胶囊混悬液,记录小鼠毒副反应情况,并测定实验小鼠灌胃给药半数致死量(LD50)。结果实验小鼠灌胃给药的半数致死量为23.54 g/kg,相当于临床剂量的343.40倍。结论临床应用紫茜抗癌胶囊安全可靠。
Objective To observe the toxicity of ZIQIAN anticancer capsule. Methods Experimental mice were administered different concentration suspension of ZIQIAN anticancer capsule, its acute toxic reactions were observed, and LDs0 was determined after intragastric administration. Results LD50 was 23.54g ·kg^-1 , equivalent to clinical dose by 343.40 times. Conclusion The dose of ZIQIAN anticancer capsule is safe in clinic use.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2009年第9期2230-2231,共2页
Lishizhen Medicine and Materia Medica Research
基金
吉林省科技厅重点项目(No.20050909)
