摘要
目的:探讨钒化钠对人食管癌细胞系EC109 MAPK信号通路中ERK1/2表达的影响。方法:用半定量Western-blot方法检测ERK1/2蛋白的表达水平。结果:一定浓度的钒化钠对食管癌细胞系EC109 MAPK信号通路中ERK1/2表达有抑制作用。结论:一定浓度的钒化钠能明显抑制食管癌细胞系EC109细胞株的生长,钒化钠的抗肿瘤机制可能与ERK1/2蛋白表达水平降低有关。
Objective： To evaluate the effect of sodium vanadate on the expression of ERK1/2 in the esophageal cancer cell line EC109. Methods： Western blot analysis was applied to determine modification of ERK1/2 proteins. Results： The expression of ERK1/2 was evidently decreased by sodium vanadate of certain concentration. Conclusion： Sodium vanadate significantly inhibits the proliferation of human esophageal cell line EC109. The antitumor mechanism of Sodium vanadate may he related to down--regulation of ERK1/2 expression.
出处
《包头医学院学报》
CAS
2009年第4期1-2,共2页
Journal of Baotou Medical College
基金
国家自然科学基金资助项目(30360041)
内蒙古自治区教育厅资助项目(NJ06011)
秦文斌教育基金(NO200708)
关键词
钒化钠
食管癌
信号转导
ERK1/2
Sodium vanadate
Esophageal cancer
Signal transduction
ERK1/2
