沙美特罗/丙酸氟替卡松干粉剂吸入治疗成人中、重度支气管哮喘急性发作期的疗效观察被引量：3

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摘要目的:观察沙美特罗/丙酸氟替卡松干粉剂吸入治疗中、重度支气管哮喘急性发作期的疗效。方法:将60例患者随机分为观察组和对照组,其中观察组30例,对照组30例。两组患者均给予低流量吸氧、止咳、化痰等治疗。观察组在此基础上加用沙美特罗/丙酸氟替卡松干粉剂50μg/250μg每日2次吸入;对照组给予传统疗法,即β2受体激动剂(如博利康尼、美喘清)和氨茶碱口服或静脉滴注。两组均根据病情给予肾上腺皮质激素口服或静脉滴注治疗。两组患者每天评定一次疗效,观察症状、体征完全消失时间。结果:观察组总有效率和显效率分别为97%、90%,对照组总有效率和显效率分别为73%、50%,两组比较差异有统计学意义。结论:沙美特罗/丙酸氟替卡松干粉剂吸入在成人中、重度急性哮喘发作时可以较快地缓解症状、控制病情、缓解咳喘症状及较少有不良反应,是治疗急性哮喘发作的有力措施,值得进一步推广使用。

作者刘卿华

机构地区燕岭医院门诊部

出处《包头医学院学报》 CAS 2009年第4期53-55,共3页 Journal of Baotou Medical College

关键词沙美特罗丙酸氟替卡松支气管哮喘急性发作期

分类号 R562.25 [医药卫生—呼吸系统]

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1WHO/NHLIB Workshop Report. Global strategy for asthma management and prevention [ C]. NIH publication No. 02-3659,2002:127-128.
2中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗及教育和管理方案)[J].中华结核和呼吸杂志,2003,26(3):132-138. 被引量：3565
3Mak JC, Nishikawa M, Barnes PJ. Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human Lung[J]. Am J Physiol,1995,268(1Pt 1) :L41-L46.
4Baraniuk JN, Ali M, Brody D, et al. Glucocorticoids induce beta 2- adrenergic receptor function in human nasal mucosa [J]. Am J Respir Crit Care Med,1997,155:704-710.
5Eickelberg O, Roth M, Lorx R, et al. Ligand- independent activation of the glucocortieoid receptor by beta 2 adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells[J].J Biol,Chem, 1999,274 : 1005 - 1010.
6Johnson M. Pharmacology of long-acting beta-agonists[J].Ann Allergy Asthma Immunol, 1995,75 : 177- 179.
7Barnes PJ. Molecular mechanisms of steroid action in asthma [J].J Allergy Clin Immunol,1996,97(1Pt 2) :159-168.
8Pang L, Knox AJ. Synergistic inhibition by β2- agonists and corticosteroids on tumor necrosis factor-alpha-induced interieukin-8 release from cultured human airway smooth-muscle cells[J]. Am J Respir Cell Mol Biol, 2000,23(1) :79-85.
9Silvestri M,Fregonese L,Sabatini F, et al. Fluticasone and salmeterol downregulate in vitro fibroblast proliferation and ICAM-1 or H-CAM expression[J]. Eur Respir J, 2001,18(1) :139-145.
10Sposistra FM,Postma DS, Hovenga H,et al. Additive anti -inflammatory effect of formoterol and budesonide on human ling fibroblasts[J]. Thorax, 2002,57 (3) : 237 - 241.