摘要
目的探讨幽门螺杆菌（Ｈｐ）相关性胃炎患儿的胃肠动力变化特点。方法应用放射免疫分析和食管胃ｐＨ监测技术对５８例Ｈｐ阳性和４７例Ｈｐ阴性慢性胃炎患儿的血清胃泌素、血浆胃动素、十二指肠胃食管返流等进行了对比研究。结果Ｈｐ阳性组血清胃泌素水平高于Ｈｐ阴性组和正常对照组（ｔ值分别为３．３２６、３．８３７，Ｐ均＜０．０１）；Ｈｐ阳性组血浆胃动素水平低于Ｈｐ阴性组和正常对照组（ｔ值分别为２．５９４、４．４３２，Ｐ＜０．０５和０．０１）。Ｈｐ阳性组胃食管返流发生率为２１％，低于Ｈｐ阴性组中的４８％（χ２＝３．８１２，Ｐ＞０．０５）；Ｈｐ阳性组十二指肠胃返流发生率为５０％，高于Ｈｐ阴性组中的１３％（χ２＝７．３８３，Ｐ＜０．０１）。结论Ｈｐ感染可以导致慢性胃炎患儿血中胃泌素水平升高和血中胃动素水平降低；Ｈｐ相关性胃炎患儿胃食管返流的发生有减少的可能。
Objective To explore the charateristics of gastrointestinal motility of Helicobacter pylori (Hp)associated gastritis in children. Methods Serum gastrin, plasma motilin and duodenogastroesophageal reflux of 105 patients with chronic gastritis including 58 Hppositive and 47 Hpnegative patients were studied with radioimmunoassay and gastroesophageal three pH monitoring technique. Results The level of serum gastrin in Hp positive group was higher than that in Hpnegative group and normal control group (t=3.326 and 3.837, both P<0.01); the level of plasma motilin in Hppositive group was lower than that in Hpnegative group and normal control group (t=2.594 and 4.432, P <0.05 and P<0.01). The gastroesophageal reflux rate in Hppositive patients (21%) was lower than that in Hpnegative patients (48%) (χ2=3.812, P>0.05); the duodenogastric reflux rate in Hppositive patients (50%) was higher than that in Hpnegative patients (13%) (χ2=7.383, P<0.01). Conclusion Hp infetion may result in remarkable raising of serum gastrin and marked decline of plasma motilin in children with chronic gastritis. In children with Hpassociated gastritis the gastroesphageal reflux rate tended to decrease, while the duodenogastric reflux rate tended to increase.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1998年第8期482-484,共3页
Chinese Journal of Pediatrics
关键词
幽门螺杆菌
胃炎
胃肠活动
胃肠激素
儿童
Helicobacter pylori Gastritis Gastrointestinal motility Gastrointestinal hormones
