摘要
肠源性内毒素可使脏器中ＰＧＦ１α／ＴＸＢ２发生改变。为研究该变化对组织脏器的影响，本实验采用腹膜炎大鼠模型检测其肝、肺、胃、肠、肾组织中ＰＧＦ１α／ＴＸＢ２含量，并观察通里攻下法对它们的作用。结果表明：腹膜炎所造成的肠源性内毒素血症，可使脏器中ＰＧＦ１α／ＴＸＢ２比值下降，引起组织脏器损害。而通里攻下法可对调节腹膜炎大鼠脏器组织中ＰＧＦ１α／ＴＸＢ２的平衡具有显著作用，故可改善机体的微循环状态，降低脏器组织的病理损害程度。本研究为临床应用通里攻下法治疗肠源性内毒素血症，提供了进一步的实验依据。
ntestinal endotoxin can alter the ratio of PGF1α/TXB2 in organs.Models of rates with peritonitis were used. The levels of PGF1α/TXB2 in tissues of the liver,lung,stomach,intestine and kidney were tested. In addition,the effect of the TCM purgative method on them was observed. The results indicated that intestinal endotoxemia following peritonitis could decrease the ratio of PGF1α to TXB2,thus causing the damage of the organs. However,the TCM purgative method could adjust the balance of PGF1α with TXB2,improve the status of microcirculation,reduce damages in the organs. It was suggested that intestinal endotoxemia might effectively be treated by purgative method of TCM (Tongli Gongxia)
出处
《中国中西医结合外科杂志》
CAS
1998年第2期76-78,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
