摘要
目的:观察自早卵泡期或中晚卵泡期开始加入HMG的CC/HMG/HCG促排卵方案对PCOS不孕患者的治疗效果。方法:对18例PCOS不孕患者共36个周期进行自身对照的回顾性分析,其中早卵泡期低剂量HMG序贯方案(A组)和中晚卵泡期方案(B组)各18周期,观察两种方案的治疗效果及异常反应。结果:A组的HMG用量、用药天数以及中小卵泡数均明显少于B组(P<0.05);A组无卵巢反应不良周期,B组有5个周期卵巢无反应(P<0.05);两组HCG日大卵泡数、内膜厚度、妊娠率、排卵率、单卵泡发育周期数差异无统计学意义(P>0.05)。两组各发生1例轻度OHSS。结论:CC/HMG/HCG方案是治疗PCOS不孕患者的有效方法,其中早卵泡期低剂量HMG序贯方案更加经济、有效、安全。
Objective： To observe the curative effect of CC/HMG superovulation protocols added by HMG at early follicular phase and mid - or late follicular phase on infertile women with polycystic ovary syndrome. Methods： 18 patients with polycystic ovary syndrome undergoing ovarian superovulation for 36 treatment cycles were analyzed retrospectively by self control. 18 cycles received the project which HMG was administrated in contiguous low dose from early follicular phase （Group A） , while HMG was administrated other 18 cycles from mid - or late follicular phase （ Group B） . The outcomes and adverse effects were compared between the two groups. Results ： The total HMG dose, duration of HMG treatment （days） and the number of medium and small follicles in Group A were significantly lower than those in Group B （P 〈 0. 05 ） ; Group A had no unresponsive cycles, nevertheless, Group B had 5 unresponsive cycles （ P 〈 0. 05 ） . There was no significant difference in the number of lager follicles, endometrial thickness, ovulation rate, pregnancy rate and single follicles cyclogeny at the time of HCG administration between the two groups （ P 〉 0. 05 ） . Both of the two groups had one patient with OHSS. Conclusion ： CC/ HMG/HCG protocol is effective in the treatment of infertile women with polycystic ovary syndrome, especially HMG administration in contiguous low dose at early follicular phase, which is economic, effective and safe.
出处
《中国妇幼保健》
CAS
北大核心
2009年第27期3864-3866,共3页
Maternal and Child Health Care of China
关键词
多囊卵巢综合征
促排卵
克罗米芬
人尿促性腺激素
Polyeystie ovary syndrome
Superovulation
Clomiphene
Human menopausal gonadotropin
