摘要
骨质疏松与某些矿物质的饮食摄取不足、过量或不平衡有关，但微量元素在骨质疏松的病理、诊断和治疗中也起着十分重要的作用。适量的B、F、Si、Mn、Cu、Zn、Ge、Sr和V、I、Mo对骨骼的发育和代谢是必需的，但Pb、Cd、Al则可能是骨质疏松的危险因子。高尿锌可被用作骨质疏松的生物化学标记物，锶可代替钙用作骨矿化的标记物。临床实践表明，氟可明显增加骨质疏松患者的长轴骨密度和显著降低脊椎骨新骨折的发生率；锶因能降低骨吸收和维持相对高的骨形成而被列为骨质疏松症的新治疗对策；有机锗Ce－132有望成为骨细胞激活剂；补充钙的老年妇女如果同时补充适量铜、锌、锰可进一步阻止骨矿密度的损失。
A review with 38 references is given on the connection between osteoporosis and trace element.Osteoporosis is closely related to deficiency, excess or imbalance of some minerals in dietary intake.Trace elements also play an important role in the pathogenesis, diagnosis and treatrment of osteoporosis.Appropriate amount of B, F, Si, Mn, Cu, Zn, Ge, Sr and V, I, Mo is essential and beneficial for nounal development and metabolism of skeletons in human beings and animals. However, Pb, Cd, Al may he a potentialy risking factor for osteoporosis. Hyperzincuria has been proposed as a biochemical marker in osteoporosis. Strontium is currently used as a marker of calcium in the studies of human bone mineralization. Clinical practices or preclinical studies clearly indicate that fluoride could increase the bone density of the axial skeleton and decrease the incidence of new vertebral fractures in osteoporotic subject; strontium salts could decrease bone resorption and maintain a relative high bone formation , which has been suggested as one of new treadment strategies; organic germanium Ge - 132 is considered as an activator of osteoblast; spinal bone loss in calcium-supplemented older postmenopausal woman can he furtherly arrested by concomitant increase in trace elements (Cu, Zn, Mn) in take.
出处
《广东微量元素科学》
CAS
1998年第8期1-12,共12页
Trace Elements Science
关键词
骨质疏松
微量元素
硼
锶
治疗
骨折
Osteoporosis, Trace element, Boron, Strontium, Fluoride, Zinc
