摘要
目的评价不同含碘量食盐防治碘缺乏病的效果。方法采用Cochrane系统评价的原理与方法，通过计算机检索的CochraneLibrary（1994-）、Medline光盘数据库（1966-）、BA数据库（1969-）、PubMed（1950-）、OVID数据库（1950-）、ISI Web of Knowledge（1966-）、维普中文科技期刊数据库（1989-）、万方数据库（1997-）、中国生物医学文献光盘数据库（1978-）、CNKI（1994-），并手工检索《中华预防医学杂志》（1953-）、《中国地方病学杂志》（1986-）、《中华流行病学杂志》（1981-）、《中国地方病防治杂志》（1986-）、《地方病通报》（1986-）、《现代预防医学》（1975-）6种杂志，时间均截止到2007年3月。按照纳入、排除标准纳入合格的有效文献，并对其进行严格的质量评价，对结果进行描述性分析及定性综合。结果共纳入13项观察。前6项观察为设有对照的干预试验。其中2项为社区干预试验，采用不同含碘量的食盐对人群实施干预；4项为随机对照试验，比较碘盐和其他干预措施对碘缺乏病的防治效果。另外7项为横断面调查，分析盐含碘量下调后，人群碘营养状况。经过分析显示，食用低碘盐的人群尿碘水平较为合理，甲状腺肿大率也明显下降。结论碘盐被认为是预防碘缺乏病最好的补碘方法，但不同含碘量食盐对碘缺乏病的防治效果有不同。适当的降低盐含碘量不仅能达到防治碘缺乏病的目的．而且能使由于碘摄人过量导致的副作用降到最低．同时可以节约大量的碘资源。目前，尚需要开展高质量、大样本的社区干预试验，以深入探讨不同加碘量的食盐对碘缺乏病的防治效果。
Objective To assess the effectiveness of different concentration of iodized salt for preventing iodine deficiency disorders. Methods Using the principle and method of systematic review, we searched Cochrane Library（from 1994 to Mar. 2007）, Medline（from 1966 to Mar. 2007）, BA（from 1969 to Mar. 2007）, PubMed（from 1950 to Mar. 2007）, OCID（from 1950 to Mar. 2007）, ISI Web of Knowledge（from 1966 to Mar. 2007）, Vip （from 1989 to Mar. 2007）, Wanfang（from 1997 to Mar. 2007）, CBMDisc（from 1978 to Mar. 2007） and CNKI（1994 to Mar. 2007） and hand searched 6 relevant Chinese journals, including Chinese Journal of Preventive Medicine, Chinese Journal of Endemiology, Chinese Journal of Epidemiology, Chinese Journal of Control of Endemic Disease, Endemic Diseases Bulletin and Modern Preventive Medicine. We screened the for eligible studies according to the inclusion and exclusion criteria to be rigorously evealuated descriptly and qualitatively. Results Thirteen studies were included, of which, the first six were intervention trials with comparison, including two community intervention trials, which classified all objects into different groups, using iodized salt at different concentration as intervention, four were RCTs with different intervention methods, compare the iodized salt with other intervention measures. Seven were cross-sectional studies, which analyzed the iodine nutrition of people after the concentration of iodized, salt was lowered down. Because of different interventions in control groups and different outcome measures, it was difficult to perform meta-analysis, a descriptive analysis of the results was presented. Most studies showed that urinary iodine level decreased as the concentration of iodized salt went down gradually. When the concentration of iodized salt went down to the best level recommended, goiter rate decreased obviously. Conclusions Iodized salt was considered as the best method of iodine supply to prevent iodine deficiency disorders. But effectiveness of preventing iodine deficiency disorders with various concentration of iodized salt is different. To lower the concentration of iodized salt properly can not only prevent iodine deficiency disorders but also reduce the side effect of excess iodine intake to the minimum. And it can also save a lot of iodine resource. Well-designed community-based intervention trials with large sample size are needed to confirm the effect of different concentration of iodized salt on preventing iodine deficiency disorder.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2009年第5期579-582,共4页
Chinese Jouranl of Endemiology
基金
重庆市“十一五”科技发展规划重大专项（CSTC2007AB5034）
重庆医科大学2007年度校级课题基金（XBYB2007072）
关键词
碘
缺乏症
尿
盐类
系统评价
Iodine
Deficiency diseases
Urine
Salts
Systematic review
