摘要
目的:检测并分析ER和PR在乳腺癌中的表达,探讨ER、PR在内分泌治疗中的作用。方法:选取137例有完整临床和病理资料的乳腺癌患者,采用免疫组化法检测其乳腺癌组织中的ER、PR表达。结果:ER,PR阳性率分别为55.47%,51.09%,PR(+)患者,其ER大多数表达阳性;绝经后ER阳性患者较绝经前患者多;ER、PR阳性率表达与淋巴结是否转移无明显相关性。结论:ER和PR在乳腺癌组织中的存在可以预测肿瘤对激素治疗是否敏感,为临床指导辅助内分泌治疗提供有力的证据。
Objective ： To study the expressions of estrogen receptors （ER） and progesterone receptors （PR） in breast cancer tissues. Methods： Total of 137 cases of breast cancer with complete clinical and pathological data were selected and tested expression of ER, PR by immunohistochemical method. Results： The expressions rates of ER,PE were 55.47% ,51.09% ,respectively. The expressions of PR was correlated with the expression of ER. A positive correlation was found between expression of PR, ER and age. The expression of ER, PR in breast cancer had no relation with metastasis of axillary lymphnode. Conclusion： ER and PR in breast cancer tissue can predict the existence of tumor is sensitive to the hormone therapy for clinical treatment guide - assisted endocrine evidence.
出处
《现代肿瘤医学》
CAS
2009年第10期1877-1878,共2页
Journal of Modern Oncology
关键词
雌激素受体
孕激素受体
乳腺癌
辅助内分泌治疗
estrogen receptors
progesterone receptors
breast cancer
adjuvanticity endocrine therapy
