摘要
目的了解杭州市城镇妊娠妇女在不同孕期甲状腺功能状况,为今后实施孕妇甲状腺功能筛查的必要性和可能性提供依据。方法随机采集杭州市5个调查点160名妊娠妇女及51名正常非妊娠妇女的血、尿标本,化学发光法测定TSH、FT4、FT3、TT4、TT3、TPOAb和TGAb,尿碘采用酸消化砷-铈接触法。结果①妊娠早、中、晚期妇女的尿碘中位数分别为157.30μg/L、177.95μg/L、162.15μg/L,与非妊娠妇女(对照组,中位数值为170.50μg/L)差异无统计学意义(Z=-0.60,P=0.55;Z=-0.93,P=0.35;Z=-1.40,P=0.16);②妊娠早期妇女TSH水平显著低于非妊娠妇女,FT4随孕龄增加而逐渐降低,TT4和TT3水平自孕早期开始即明显高于非妊娠妇女,TT4至孕中期时达峰值,是非妊娠水平的1.41倍,TT3至孕晚期时达峰值,是非妊娠水平的1.55倍;③不同妊娠期妇女TSH、FT4与正常参考值比较,结果均有90%以上的人其值在正常范围;④203名调查对象中10.3%(21/203)为自身抗体阳性者,其中非妊娠妇女中6例,妊娠妇女中15例阳性,阳性率分别为14.0%(6/43)和9.4%(15/160)。结论①从群体的角度来看,杭州市城镇妊娠妇女碘营养处于适宜水平;②妊娠期妇女甲状腺功能状况不同于非妊娠妇女,而且不同孕期也有显著差别;③杭州市城镇妊娠妇女TSH、FT4总体水平处于正常。
Objective To investigate thyroid function in pregnant women during different trimesters of pregnancy in Hangzhou City,and to provide evidence for the necessity and probability of screening for thyroid functions.Methods The urinary iodine levels and indexes of thyroid function of 160 pregnant women and 51 non-pregnant women were determined.The urinary iodine level was measured by spectrophotometer method.The levels of thyroid-stimulating hormone（TSH）,free thyroxine（FT4）,free triiodothyronine（FT3）,total thyroxine（TT4）,total triiodothyronine（TT3）,thyroid peroxidase antibody（TPOAb）and thyroglobulin antibody（TGAb）were measured by a chemiluminescence assay.Results ① The median urinary iodine concentrations during the first,second and third trimesters of pregnancy were 157.30 μg/L,177.95 μg/L and 162.15 μg/L,respectively,and were all not significantly different from that of non-pregnant women,which was 170.50 μg/L（Z=-0.60,P=0.55;Z=-0.93,P=0.35;Z=-1.40,P=0.16）.② The serum TSH level during the first trimester was obviously declined compared with that of the non-pregnant women.FT4 levels were gradually decreased with increasing gestational age.The TT4 level was markedly elevated and reached peak at the sencond trimester,approximately 1.41 times of that in non-pregnant women,and the TT3 levels reached peak at the third trimester,approximately 1.55 times of that in non-pregnant women.③ Compared with the normal values of TSH and FT4,the values of more than 90% of the pregnant women were in the normal range.④ Of the 21（10.3%）autoantibody-positive women,6 were non-pregnant and 15 were pregnant.Conclusion ① The nutritional status of iodine was optimized in pregnant women in Hangzhou City.② The thyroid hormone levels were completely different from that of the non-pregnancy and among gestation periods.③ The levels of TSH,FT4 in pregnant women of Hangzhou City were in normal status.
出处
《中国预防医学杂志》
CAS
2009年第9期801-803,共3页
Chinese Preventive Medicine
基金
浙江省医药卫生科学研究基金项目(基金编号:2007B186)
关键词
妊娠妇女
甲状腺功能
城镇
Pregnant women
Thyroid function
Urban areas
