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DJ-1基因:抗帕金森病药物作用的可能新靶点 被引量：3

DJ-1 gene:a new potential target of drugs for Parkinson's disease
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摘要 帕金森病是一种常见于中老年人群的神经系统退行性疾病,其发病与环境因素和遗传因素相关。DJ-1的基因突变和氧化损伤分别与家族性和散发性帕金森病相关。DJ-1基因突变或氧化损伤导致帕金森病的机制包括氧化应激、线粒体损伤和蛋白酶体损伤。此外,DJ-1还是散发性帕金森病的生物标记物,并且有可能成为抗帕金森病药物作用的潜在新靶点。 Parkinson＇ s disease （PD） is a neurodegenerative disease commonly found in middle-aged and elderly people, and its onset is attributable to both genetic and environmental factors. The gene mutation and oxidative damage of DJ-1 correlate with familial and sporadic PD, respectively. The mechanisms by which DJ-1 gene mutation and oxidative damage lead to PD in-clude oxidative stress, mitochondrial dysfunction and proteasome dysfunction. Furthermore, DJ-1 is a biomarker of sporadic PD and it may become a new potential target of anti-PD drugs.
作者 张宏宁 安春娜 蒲小平
机构地区 北京大学天然药物与仿生药物国家重点实验室 北京大学药学院分子与细胞药理学系
出处 《中国药理学通报》 CAS CSCD 北大核心 2009年第9期1138-1141,共4页 Chinese Pharmacological Bulletin
基金 国家重点基础研究发展计划(973计划)资助项目(No2004CB518902)
关键词 DJ-1 帕金森病 靶点 氧化应激 分子伴侣 转录调节 D J-1 Parkinson ＇ s disease target oxidative stress chaperone thanscription regulation
分类号 R-05 [医药卫生] R394.2 [医药卫生—医学遗传学]
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参考文献25

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二级参考文献42

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共引文献3

同被引文献27

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引证文献3

二级引证文献10

中国药理学通报
2009年 第9期

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