摘要
目的观察复方氟尿嘧啶多相脂质体(co-FU)腹腔灌注辅助手术切除治疗进展期贲门癌的疗效,及切除标本中化疗药物的浓度。方法将20例进展期贲门癌患者随机分为观察组和对照组,各10例。术前2 d分别予co-FU2.66 mg/kg、5-FU16.66 mg/kg腹腔灌注1次/d,术日术前60 min给药后行贲门癌根治术。术中切取贲门癌癌灶、大网膜、正常胃黏膜、胃左淋巴结、下肺韧带淋巴结,采用高效液相色谱法检测标本中的药物浓度。结果术后随访12个月,观察组发生腹腔淋巴结转移1例,无腹水出现者;对照组分别为5例、2例;两组比较,P<0.01;观察组各标本中药物浓度均高于对照组(P均<0.01)。结论co-FU腹腔灌注联合手术切除治疗进展期贲门癌安全有效,切除标本中药物浓度高。
Objective To observe the effect of surgery operation assisted with co-Fluorouracil（co-FU） liposome peritoneal perfusion on advanced gastric cardia carcinoma. Methods 20 patients with advanced gastric cardia carcinoma were randomly divided into 2 groups： experimental group（co-FU peritoneal perfusion group） and contral group （5-FU peritoneal perfusion group）, co-FU（2.66 mg/kg） was administered in experimental group and 5-FU 16.66 mg/kg was administered in contral group,139-3 co-FU or 5-FU were all given once a day and 60 min before operation. Operation was performed , tumor tissues and tissues beside cancer were obtained during operation. The drug concentration （DC） of different specimens and CD4^＋ ,CD8^＋ and WBC,AST and ALT were examined before and after drug administration. Results There were better healing effect of experimental group in near term than that of contral group （ P 〈 0.01 ）. The DC of cancer tissue and tissues beside cancer was significantly higher than that of contral group（ P 〈 0.01 ）. There were no difference of the CD4^＋, CD8^＋, CD;/CDs ratio and WBC, AST, ALT between pre and post chemotherapy in the both groups （ P 〉 0.05） Conclusions co- FU peritoneal perfusion has more DC character in cancer tissue and tissues beside cancer than 5-FU. It is security and effective for advanced gastric cardia carcinoma.
出处
《山东医药》
CAS
北大核心
2009年第34期12-14,共3页
Shandong Medical Journal
基金
河北省普通高等学校强势特色学科建设基金资助项目(2005-52)
关键词
贲门肿瘤
复方氟尿嘧啶多相脂质体
腹腔灌注
外科手术
gastric eardia neoplasm
co-Fluorouracil liposome
peritoneal perfusion
surgery operation
