摘要
目的探讨巨噬细胞移动抑制因子（MIF）基因-173G〉C位点多态性与中国南方汉族人群膀胱癌的关系。方法用聚合酶链反应．限制性片段长度多态性（PCR—RFLP）检测年龄和性别匹配的中国南方汉族217例膀胱癌患者和249例正常人群的MIF-173G〉C基因型。通过分层分析探讨年龄、性别、吸烟和饮酒对罹患膀胱癌的影响。结果与-173GG比较，携带MIF-173GC／CC基因型者可降低罹患膀胱癌的危险性（OR=0．63，95％CI=0．43～0．93）。分层分析结果显示，年龄大（〉55岁）的男性在吸烟和饮酒下携带-173GC／CC基因型具有保护作用（年龄〉55岁：OR=0．58，95％CI=0．38～0．89；男性：0．51、0．33～0．78；吸烟：0．50、0．29～0．86；饮酒：0．40、0．23～0．70）。结论MIF-173G〉C多态性可能与我国汉族人群膀胱癌发生有关。
Objective To investigate the association between the - 173G 〉 C polymorphism in the macrophage migration inhibitory factor （MIF） gcnc and bladder cancer risk in a southern Chinese population. Methods The polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） technique using genomic DNA isolated from 217 bladder cancer patients, and 249 age-and sex-matched controls. Stratification analysis by age, sex, smoking status, and alcohol status was performed. Results Compared with the - 173GG genotype,individuals with GC/CC genotypes had a significantly decreased risk of bladder cancer （ OR = 0.63,95% CI = 0. 43-0.93 ）. The stratification analysis revealed that the decreased risk was more pronounced among older subjects （0.58,0.38- 0.89） ,men （0.51,0.33-0.78） ,smokers （0.50,0.29-0.86） ,and drinkers （0.40,0.23-0.70）. Conclusion Our data suggest that MIF-173G 〉 C polymorphism may contribute to the etiology of bladder cancer in a southern Chinese population.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2009年第10期1250-1252,共3页
Chinese Journal of Experimental Surgery
