摘要
目的探讨整合素β3（Integrin-β3）和Fas蛋白在胃癌组织中的表达、相互关系及意义。方法应用免疫组织化学方法检测48例胃癌组织及12例正常胃黏膜中Integrin-β3和Fas蛋白的表达。结果胃癌组织中Integrin-β3阳性率显著高于正常胃黏膜（72．9％比25．0％，P〈0．01）；正常胃黏膜中Fas蛋白阳性率显著高于胃癌组织（83．3％比33．3％，P〈0．01）；Integrin-β3阳性率与淋巴结转移、TNM分期显著相关（P〈0．01），而与肿瘤细胞分化程度无相关性（P〉0．05）；Fas蛋白阳性率与淋巴结转移、TNM分期及肿瘤细胞分化程度均无相关性（P均〉0．05）。胃癌组织中Integrin-β3与Fas表达具有显著等级负相关（r=-0．429，P〈0．01）。结论Integrin-β3的表达与胃癌细胞的浸润与转移密切相关。
Objective To investigate the expression of Integrin-β3 and Fas protein in gastric carcinoma as well as their relationships with clinical characteristics. Methods The expression of Integrin-β3 and Fas protein was detected by using immunohistochemical technique in the specimens from 48 cases of gastric carcinoma tissues and 12 cases of surrounding normal tissues. Results The positive rate of Integrin-β3 expression was significantly higher in gastric carcinoma than that in the normal tissues （72.9% vs 25.0%, P 〈 0.01 ）, while that of Fas expression was marked significantly lower in gastric carcinoma than that in the normal controls （33.3% vs 83.3% ,P 〈0.01 ）. The expression of Integrin-β3 was correlated with lymph node metastasis and TMN staging （P 〈 0. 01 ）, but not with the differentiation of tumor cells （P 〉 0. 05）. The expression of Fas was not correlated with lymph node metastasis, TMN staging and the differentiation of tumor cells （P 〉 0.05）. There was a inverse correlation between the expression of Integrin-β3 is in gastric carcinoma （r = -0. 429, P 〈 0. 01 ）. Conclusion The expression of Integrin-β3 is closely correlated with the infiltration and metastasis of gastric carcinoma.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2009年第10期1341-1342,F0003,共3页
Chinese Journal of Experimental Surgery
关键词
胃癌
整合素Β3
FAS
细胞黏附分子
Gastric carcinoma
Integrin-β3
Fas
Cell adhesion molecule
