摘要
目的了解６０Ｃｏ与深部Ｘ线对于颌骨的损害效应以深入研究颌骨放射性骨坏死（ＯＲＮＪ）的发病机理。方法采用两种放射源按各种不同剂量分割条件对１２８只豚鼠右侧颌骨照射，并于放疗前后一定时期拔牙，定期进行颌骨局部Ｘ线摄片和组织病理学检查。结果深部Ｘ线照射豚鼠无论是颌骨损害程度还是全身反应远较６０Ｃｏ为严重，照射后１月内成骨细胞抑制，破骨细胞活动亢进，因而出现骨质吸收；２～４月后骨细胞数目减少，核固缩，空虚陷窝增多，牙周膜内小血管闭塞。放疗后３、５月拔牙共有７例（１４．６％）发生了ＯＲＮＪ。结论相同剂量的深部Ｘ线对颌骨组织的损害程度大大超过６０Ｃｏ；
Objective Study of the effects of 180kv x ray and cobalt 60 radiation on jaws and enhance the understanding of pathology of osteoradionecrosis of jaws (ORNJ).Methods 128 guinea pigs were grouped according to different irradiation sources and doses.Fractioned radiation from both sources was delivered in right mandible.The teeth extractions were conducted one week prior to radiation and 1,3,5 months after radiation respectively.Following radiation,the guinea pigs were examined by gross observation,x ray film and histopathological examination at regular interval.Results Bone resorption occured within 1 month after irradiation as result of osteoblast inhibition and osteoclast activation.From 2 to 4 month afterwards,the number of osteocytes reduced and pyknosis,empty lacunae as well as obliteration of small vessels in periodontal membrane were commonly seen.The teeth extractions conducted at 3 months ,5 months after radiation lead to ORNJ in 7 amimals (14.6%).Conclusion 180kv x ray radiation was far more damaging to jaws than cobalt 60 radiation.The dental extraction is an important factor inducing the development of ORNJ.
出处
《上海口腔医学》
CAS
CSCD
1998年第3期125-129,共5页
Shanghai Journal of Stomatology
基金
上海市高教局博士点基金
