摘要
目的：探索藏药复方红景天（ＲＣＯ）和复方参芪花粉合剂（ＡＣＯ）对高原急性肺损伤（ＡＬＩ）早期的防治作用。方法：２４只兔和１２０只小鼠随机分为生理盐水对照组（ＮＣＧ）、盲肠结扎穿孔（ＣＬＰ）致伤组（ＩＧ），ＡＣＯ防治组（ＡＣＯＧ）、ＲＣＯ防治组（ＲＣＯＧ）。致伤前后按时测定体、肺血流动力学，血气和血、组织匀浆中的血栓素Ｂ２（ＴＸＢ２）、６酮前列腺素Ｆ１α（６ｋｅｔｏＰＧＦ１α）各指标参数。结果：各组动脉血氧分压（ＰａＯ２）和平均肺动脉压（ＭＰＡＰ）在致伤前已出现差异，ＲＣＯＧ和ＮＣＧ及ＩＧ比较，Ｐ均＜０．０５。术后４小时、８小时各组ＰａＯ２、ＴＸＢ２、６ｋｅｔｏＰＧＦ１α变化更明显，ＡＣＯＧ、ＲＣＯＧ与ＮＣＧ及ＩＧ比较，Ｐ＜０．０５或Ｐ＜０．０１。术后１２小时，ＡＣＯＧ和ＲＣＯＧ的平均体动脉压（ＭＡＰ）仍保持ＮＣＧ水平，与ＩＧ比较，Ｐ均＜０．０１。
Objective:To observe protective effects of rhodiola and astragalus compounds on acute lung injury (ALI) at high altitude.Methods:ALI was induced by cecal ligation and puncture (CLP) in rabbits and mice at high altitude.Twentyfour rabbits and 120 mice were divided into 4 groups as follows:normal control group (NCG),injured group (IG),astragalus compound treated group (ACOG),and rhodiola compound group (RCOG).The mean systemic artery pressure(MAP),mean pulmonary artery pressure (MPAP),PaO 2,PaCO 2,plasma and tissue thromboxane B 2(TXB 2),6ketoprostaglandin F 1α (6keto PGF 1α ) levels were examined before and after CLP.Results:It was shown that PaO 2 was higher and MPAP was lower in RCOG than those in NCG and IG before CLP (both P <0 05).At 4 and 8 hours after CLP,significant differences in PaO 2,TXB 2 and 6ketoPGF 1α were found between ACOG or RCOG and NCG or IG( P <0 05 or P <0 01).In addition,MAP values in ACOG and RCOG were maintained stable at 12 hours after CLP compared to normal controls,but they were decreased in IG at this time point ( P <0 01).Conclusions:Rhodiola or astragalus compound may have beneficial effects in preventing ALI at high altitude.
出处
《中国危重病急救医学》
CAS
CSCD
1998年第9期546-549,共4页
Chinese Critical Care Medicine
基金
解放军总后勤部九五科研课题
关键词
肺损伤
高原
复方红景天
参芪花粉合剂
治疗
acute lung injury\ \ high altitude\ \ rhodiola compounds\ \ astragalus compounds
