摘要
目的探讨肝病患者血清甲胎蛋白定量检测的临床意义,分析甲胎蛋白水平与肝病的相关性。方法收集130例肝病患者,其中包括急、慢性肝炎、肝硬化、重型肝炎及原发性肝癌的甲胎蛋白结果及生化学指标,分析其与病情发展的相关性。结果肝癌患者中有82.35%(14/17)甲胎蛋白升高,且明显高于其他组(P<0.01);慢性乙型重型肝炎患者的甲胎蛋白也显著升高(P<0.01),但低于肝癌患者(P<0.01),重型肝炎好转组甲胎蛋白显著高于死亡组(F=6.40,P<0.01)。结论甲胎蛋白轻度升高是重型肝炎患者预后良好的预测指标,但明显升高要警惕原发性肝癌的发生。
Objective To investigate the clinical significance of alpha fetoprotein detection in patients with liver disease and to analyze the relationship of the level of alpha fetoprotein and liver disease.Methods The level of alpha fetoprotein and biochemical indexes of 130 patients with liver disease,including acute hepatitis,chronic hepatitis,hepatic cirrhosis,sever hepatitis and primary hepatic carcinoma were detected.The changes of alpha fetoprotein in these patients were observed.Results The level of alpha fetoprotein of 82.35%（14/17） patients with primary hepatic carcinoma increased,and it was significantly higher than other groups（P〈0.01）.The level of alpha fetoprotein of patients with chronic sever hepatitis B was significantly higher than other groups（P〈0.01）,but it was significantly lower than patients with primary hepatic carcinoma（P〈0.01）.The level of alpha fetoprotein of improved group with sever hepatitis was significantly higher than death group（F=6.40,P〈0.01）.Conclusion Light increase of alpha fetoprotein is a good predictor of patients with sever hepatitis,but obvious increase of alpha fetoprotein can predict primary hepatic carcinoma.
出处
《胃肠病学和肝病学杂志》
CAS
2009年第9期834-836,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
肝病
甲胎蛋白
原发性肝癌
Liver disease
Alpha fetoprotein
Primary hepatic carcinoma
