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巨噬细胞抑制因子-1在胃癌中的作用 被引量：1

Role of macrophage inhibitory cytokine-1 in the development and progression of gastric cancer
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摘要 巨噬细胞抑制因子-1(macrophage inhibitory gytokine-1,MIC-1)是人转化生长因子β(transforming growth factor-β,TGF-β)超家族中的一个重要分支成员,在胃癌等多种肿瘤有过度表达.大量研究表明,MIC-1在胃癌早期通过诱导凋亡和抑制过度增生表现抑癌生物学活性,但近期有报道,在胃癌进展期因为内环境等的变化,MIC-1具有促癌作用,其机制包括:抑制连环蛋白cateninδ1基因的表达;上调uPA系统增强胃癌肿瘤细胞侵袭性;诱导ErbB2受体酪氨酸激酶在人体胃癌细胞等过度表达.胃癌组织过度表达MIC-1和uPA提示预后不良,故可以作为判断胃癌预后的指标. Macrophage inhibitory cytokine-1（MIC-1） is a divergent member of human transforming growth factor β（TGF-β） superfamily, which is overexpressed in a variety of human cancers, including gastric cancer. Numerous studies have shown that MIC-1 exerts tumor-suppressing activity through inducing apoptosis and inhibiting excessive proliferation in early gastric cancer. However, recent reports show that MIC-1 may contribute to the malignant progression of gastric cancer because of changes in internal environment in advanced gastric cancer. The mechanisms involved include： inhibiting the expression of catenin 61 gene, upregulating the urokinase plasminogen activator （uPA） system to enhance invasiveness of gastric cancer cells, and inducing overexpression of ErbB2 receptor tyrosine kinase in human gastric cancer cells. The overexpression of MIC-1 and uPA in gastric cancer cells indicates a poor prognosis. Therefore, MIC-1 and uPA can be used as indicators to predict the prognosis of gastric cancer.
作者 杜中红 魏晓萍 惠起源
机构地区 延安大学医学院
出处 《世界华人消化杂志》 CAS 北大核心 2009年第22期2272-2276,共5页 World Chinese Journal of Digestology
关键词 巨噬细胞抑制因子-1 胃癌 预后 Macrophage inhibitory cytokine-1 Gastric cancer Prognosis
分类号 R735.2 [医药卫生—肿瘤]
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参考文献30

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二级参考文献71

共引文献31

同被引文献22

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世界华人消化杂志
2009年 第22期

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